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Associations between dietary inflammatory scores and biomarkers of inflammation in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
Paris-Saclay University, UVSQ, Gustave Roussy, Inserm, CESP, Team “Exposome and Heredity”, Villejuif, France.
Paris-Saclay University, UVSQ, Gustave Roussy, Inserm, CESP, Team “Exposome and Heredity”, Villejuif, France; Department of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts, MA, Amherst, United States.
Nutrition and Metabolism Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France.
Paris-Saclay University, UVSQ, Gustave Roussy, Inserm, CESP, Team “Exposome and Heredity”, Villejuif, France.
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2023 (English)In: Clinical Nutrition, ISSN 0261-5614, E-ISSN 1532-1983, Vol. 42, no 7, p. 1115-1125Article in journal (Refereed) Published
Abstract [en]

Background: Since the first version of the dietary inflammatory index (DII®) developed in the past decade, several other versions have been developed. However, to date no study has attempted to compare these versions with respect to their associations with biomarkers of inflammation.

Objective: We aimed to investigate the relationship between four dietary inflammatory scores [DII, two energy-adjusted derivatives (E-DII and E-DIIr), and the Inflammatory Score of the Diet (ISD)], and circulating levels of several inflammatory markers and adipokines.

Methods: This study included 17 637 participants from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort with at least one marker of inflammation measured in blood. Associations between the four scores and C-reactive protein (CRP), interleukin (IL)6, IL10, IL1RA, tumor necrosis factor-α (TNFα), soluble tumor necrosis factor receptor-1 (sTNFR1), sTNFR2, leptin, soluble leptin receptor (sLeptin R), adiponectin, and High Molecular Weight (HMW) adiponectin were evaluated using multivariable linear regressions adjusted for potential confounders.

Results: Positive associations were observed between the four dietary inflammatory scores and levels of CRP, IL6, sTNFR1, sTNFR2 and leptin. However, only the DII and the ISD were positively associated with IL1RA levels and only the DII and the E-DIIr were positively associated with TNFα levels. The proportion of variance of each biomarker explained by the scores was lower than 2%, which was equivalent to the variance explained by smoking status but much lower than that explained by body mass index.

Conclusions: Our results suggest that the four dietary inflammatory scores were associated with some biomarkers of inflammation and could be used to assess the inflammatory potential of diet in European adults but are not sufficient to capture the inflammatory status of an individual. These findings can help to better understand the inflammatory potential of diet, but they need to be replicated in studies with repeated dietary measurements.

Place, publisher, year, edition, pages
Elsevier, 2023. Vol. 42, no 7, p. 1115-1125
Keywords [en]
Biomarkers, Cohort, Dietary inflammatory scores, EPIC, Inflammation
National Category
Nutrition and Dietetics Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
URN: urn:nbn:se:umu:diva-209569DOI: 10.1016/j.clnu.2023.05.012ISI: 001025776600001Scopus ID: 2-s2.0-85160866795OAI: oai:DiVA.org:umu-209569DiVA, id: diva2:1765856
Funder
Region SkåneSwedish Cancer SocietySwedish Research CouncilAvailable from: 2023-06-12 Created: 2023-06-12 Last updated: 2023-09-05Bibliographically approved

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Sandström, MariaNilsson, Lena Maria

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