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Heart transplantation and biomarkers: a review about their usefulness in clinical practice
Department of Medical Biotechnology, University of Siena, Siena, Italy.
Department of Medical Biotechnology, University of Siena, Siena, Italy.
Department of Medical Biotechnology, University of Siena, Siena, Italy.
Cardio-Thoracic-Vascular Department, Siena University Hospital, Siena, Italy.
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2024 (English)In: Frontiers in Cardiovascular Medicine, E-ISSN 2297-055X, Vol. 11, article id 1336011Article, review/survey (Refereed) Published
Abstract [en]

Advanced heart failure (AdvHF) can only be treated definitively by heart transplantation (HTx), yet problems such right ventricle dysfunction (RVD), rejection, cardiac allograft vasculopathy (CAV), and primary graft dysfunction (PGD) are linked to a poor prognosis. As a result, numerous biomarkers have been investigated in an effort to identify and prevent certain diseases sooner. We looked at both established biomarkers, such as NT-proBNP, hs-troponins, and pro-inflammatory cytokines, and newer ones, such as extracellular vesicles (EVs), donor specific antibodies (DSA), gene expression profile (GEP), donor-derived cell free DNA (dd-cfDNA), microRNA (miRNA), and soluble suppression of tumorigenicity 2 (sST2). These biomarkers are typically linked to complications from HTX. We also highlight the relationships between each biomarker and one or more problems, as well as their applicability in routine clinical practice.

Place, publisher, year, edition, pages
Frontiers Media S.A., 2024. Vol. 11, article id 1336011
Keywords [en]
biomarker, CAV, heart transplantation, PGD, rejection, RVD
National Category
Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:umu:diva-221053DOI: 10.3389/fcvm.2024.1336011ISI: 001156589900001Scopus ID: 2-s2.0-85184163796OAI: oai:DiVA.org:umu-221053DiVA, id: diva2:1839574
Available from: 2024-02-21 Created: 2024-02-21 Last updated: 2024-02-21Bibliographically approved

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Henein, Michael Y.

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