Umeå University's logo

umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
LGR6 is a prognostic biomarker for less differentiated tumors in lymph nodes of colon cancer patients
Umeå University, Faculty of Medicine, Department of Clinical Microbiology. Umeå University, Faculty of Medicine, Department of Diagnostics and Intervention. Department of Biochemistry, Faculty of Science, Zagazig University, Zagazig, Egypt.
Umeå University, Faculty of Medicine, Department of Clinical Microbiology. Umeå University, Faculty of Medicine, Department of Diagnostics and Intervention. Department of Pathology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.ORCID iD: 0000-0003-3631-6122
Umeå University, Faculty of Medicine, Department of Clinical Microbiology. Umeå University, Faculty of Medicine, Department of Diagnostics and Intervention. Department of Clinical Pathology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.ORCID iD: 0000-0001-9215-7758
Department of Biochemistry, Faculty of Science, Zagazig University, Zagazig, Egypt.
Show others and affiliations
2024 (English)In: Frontiers in Oncology, E-ISSN 2234-943X, Vol. 14, article id 1393075Article in journal (Refereed) Published
Abstract [en]

Introduction: The aim was to investigate whether the stem cell marker LGR6 has prognostic value in colon cancer, alone or in combination with the prognostic biomarkers CEA and CXCL16.

Methods: LGR6 mRNA levels were determined in 370 half lymph nodes of 121 colon cancer patients. Ability to predict relapse after curative surgery was estimated by Kaplan-Meier survival model and Cox regression analyses.

Results: Patients with high LGR6 levels [LGR6(+)] had a decreased mean survival time of 11 months at 5-year follow-up and 47 months at 12-year follow-up, respectively, with hazard ratios of 3.2 and 2.8. LGR6 mRNA analysis added prognostic value to CEA and CXCL16 mRNA analysis. In the poor prognosis groups CEA(+) and CXCL16(+), further division was achieved by LGR6 analysis. LGR6(+) patients had a very poor prognosis. LGR6 also identified a small number of CEA(-), TNM stage I patients who relapsed suggesting stem cell origin of these tumors. LGR6 and LGR5 levels correlated strongly in lymph nodes of stage I and IV patients but not in stage II patients, suggesting that these stem cell markers are differentially regulated.

Conclusion: This study highlights LGR6 as a useful prognostic biomarker independently and in combination with CEA, CXCL16 or LGR5 identifying different risk groups.

Place, publisher, year, edition, pages
Frontiers Media S.A., 2024. Vol. 14, article id 1393075
Keywords [en]
cancer stem cells, CEA, colon cancer, CXCL16, LGR5, LGR6, qRT-PCR, regional lymph nodes
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:umu:diva-224262DOI: 10.3389/fonc.2024.1393075Scopus ID: 2-s2.0-85192206246OAI: oai:DiVA.org:umu-224262DiVA, id: diva2:1857654
Funder
Swedish Research Council, 2008-7042Swedish Research Council, 2010-05669Swedish Research Council, 2013-04522Region Västerbotten, RV-995803The Kempe Foundations, JCK22-0003Available from: 2024-05-14 Created: 2024-05-14 Last updated: 2024-05-14Bibliographically approved

Open Access in DiVA

fulltext(3677 kB)62 downloads
File information
File name FULLTEXT01.pdfFile size 3677 kBChecksum SHA-512
f545a7e6f829c546852bfb1cef73dae179c3ed7e85ed90ad976cf0fe4876a96cd87ed58f8b2335981c91f00354747c0669551883f0dca857e602e48ed4f6f58f
Type fulltextMimetype application/pdf

Other links

Publisher's full textScopus

Authority records

Eltorky, HagarAbdelMageed, ManarIsmail, HagerOhlsson, LinaHammarström, Marie-LouiseHammarström, StenSitohy, Basel

Search in DiVA

By author/editor
Eltorky, HagarAbdelMageed, ManarIsmail, HagerOhlsson, LinaHammarström, Marie-LouiseHammarström, StenSitohy, Basel
By organisation
Department of Clinical MicrobiologyDepartment of Diagnostics and Intervention
In the same journal
Frontiers in Oncology
Cancer and Oncology

Search outside of DiVA

GoogleGoogle Scholar
Total: 62 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 217 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf