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Glucose disturbances in very low-birthweight infants: results from the prospective LIGHT study
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Pediatrik.ORCID-id: 0000-0001-9086-7991
Umeå universitet, Samhällsvetenskapliga fakulteten, Institutionen för kost- och måltidsvetenskap.ORCID-id: 0000-0002-4649-0653
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Pediatrik.ORCID-id: 0000-0003-1816-4305
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Pediatrik.
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2024 (Engelska)Ingår i: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227Artikel i tidskrift (Refereegranskat) Epub ahead of print
Abstract [en]

Aim: To describe glucose homeostasis disturbances (dysglycaemia) in very low-birthweight infants (<1500 g) during the admission period and explore associated risk factors.

Methods: The LIGHT (very low-birthweight infants - glucose and hormonal profile over time) study was a prospective observational cohort study that included 49 very low-birthweight infants admitted to the tertiary neonatal intensive care unit in Umeå, Sweden, during 2016–2019. All glucose concentrations (n = 3515) sampled during the admission period were registered.

Results: Hyperglycaemia >10 mmol/L and hypoglycaemia <2.6 mmol/L were registered in 63% and 55% of the infants, respectively. Onset of dysglycaemia occurred almost exclusively in the first postnatal week. Hyperglycaemia followed 15% of corticosteroid doses given; all were preceded by pre-existing hyperglycaemia. Pre-existing hyperglycaemia was found in 66.7% of hyperglycaemic infants who received inotrope treatment. Upon commencement, 72.5% of antimicrobial treatments given were neither preceded nor followed by hyperglycaemia.

Conclusion: Dysglycaemia was common in very low-birthweight infants. Daily means of glucose concentrations seemed to follow a postmenstrual age-dependent pattern, decreasing towards term age suggesting a postmenstrual age-dependent developmental mechanism. The primary mechanism causing hyperglycaemia was independent of sepsis, and corticosteroid and inotrope treatments. No hypoglycaemia was registered during ongoing insulin treatment.

Ort, förlag, år, upplaga, sidor
John Wiley & Sons, 2024.
Nyckelord [en]
corticosteroids, hyperglycaemia, hypoglycaemia, sepsis, very low birthweight
Nationell ämneskategori
Pediatrik
Identifikatorer
URN: urn:nbn:se:umu:diva-228274DOI: 10.1111/apa.17370ISI: 001282268400001PubMedID: 39087626Scopus ID: 2-s2.0-85200142030OAI: oai:DiVA.org:umu-228274DiVA, id: diva2:1888075
Forskningsfinansiär
Stiftelsen Samariten, 2016- 0221Stiftelsen Samariten, 2017- 0275Stiftelsen Samariten, 2018- 0450Västerbottens läns landsting, RV-832421Västerbottens läns landsting, RV-930256Tillgänglig från: 2024-08-12 Skapad: 2024-08-12 Senast uppdaterad: 2024-08-12

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Zamir, ItayStoltz Sjöström, Elisabethvan den Berg, JohannesBerhan, YonasNaumburg, EstelleDomellöf, Magnus

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Zamir, ItayStoltz Sjöström, Elisabethvan den Berg, JohannesBerhan, YonasNaumburg, EstelleDomellöf, Magnus
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