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Evaluation of applanation resonator sensors for intra-ocular pressure measurement: results from clinical and in vitro studies.
Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper, Radiofysik.
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap.
Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper, Radiofysik.
Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Institutionen för tillämpad fysik och elektronik. Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Centrum för medicinsk teknik och fysik (CMTF).
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2003 (Engelska)Ingår i: Medical and Biological Engineering and Computing, ISSN 0140-0118, E-ISSN 1741-0444, Vol. 41, nr 2, s. 190-197Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Glaucoma is an eye disease that, in its most common form, is characterised by high intra-ocular pressure (IOP), reduced visual field and optic nerve damage. For diagnostic purposes and for follow-up after treatment, it is important to have simple and reliable methods for measuring IOP. Recently, an applanation resonator sensor (ARS) for measuring IOP was introduced and evaluated using an in vitro pig-eye model. In the present study, the first clinical evaluation of the same probe has been carried out, with experiments in vivo on human eyes. There was a low but significant correlation between IOP(ARS) and the IOP measured with a Goldmann applanation tonometer (r = 0.40, p = 0.001, n = 72). However, off-centre positioning of the sensor against the cornea caused a non-negligible source of error. The sensor probe was redesigned to have a spherical, instead of flat, contact surface against the eye and was evaluated in the in vitro model. The new probe showed reduced sensitivity to off-centre positioning, with a decrease in relative deviation from 89% to 11% (1 mm radius). For normalised data, linear regression between IOP(ARS) and direct IOP measurement in the vitreous chamber showed a correlation of r = 0.97 (p < 0.001, n = 108) and a standard deviation for the residuals of SD < or = 2.18 mm Hg (n = 108). It was concluded that a spherical contact surface should be preferred and that further development towards a clinical instrument should focus on probe design and signal analysis.

Ort, förlag, år, upplaga, sidor
2003. Vol. 41, nr 2, s. 190-197
Nyckelord [en]
resonance sensor, intra-ocular pressure
Nationell ämneskategori
Medicinsk laboratorie- och mätteknik Oftalmologi
Forskningsämne
oftalmiatrik
Identifikatorer
URN: urn:nbn:se:umu:diva-19134PubMedID: 12691439Lokalt ID: 744OAI: oai:DiVA.org:umu-19134DiVA, id: diva2:201438
Tillgänglig från: 2009-03-04 Skapad: 2009-03-04 Senast uppdaterad: 2018-06-09Bibliografiskt granskad

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Eklund, AndersLindén, ChristinaBäcklund, TomasAndersson, Britt MLindahl, Olof A

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Eklund, AndersLindén, ChristinaBäcklund, TomasAndersson, Britt MLindahl, Olof A
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RadiofysikInstitutionen för klinisk vetenskapInstitutionen för tillämpad fysik och elektronikCentrum för medicinsk teknik och fysik (CMTF)
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Medical and Biological Engineering and Computing
Medicinsk laboratorie- och mätteknikOftalmologi

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