Umeå University's logo

umu.sePublikasjoner
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Splanchnic vasoconstriction by angiotensin II is arterial pressure dependent
Umeå universitet, Medicinsk fakultet, Kirurgisk och perioperativ vetenskap, Anestesiologi och intensivvård.
Umeå universitet, Medicinsk fakultet, Kirurgisk och perioperativ vetenskap, Anestesiologi och intensivvård.
Umeå universitet, Medicinsk fakultet, Kirurgisk och perioperativ vetenskap, Kirurgi.
Vise andre og tillknytning
2002 (engelsk)Inngår i: Acta Anaesthesiol Scand, Vol. 46, nr 1, s. 57-63Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

BACKGROUND: Our hypothesis was that splanchnic vasoconstriction by exogenous angiotensin II (Ang II) is significantly potentiated by local mechanisms increasing vasomotor tone and that splanchnic tissue oxygenation during administration of Ang II is perfusion pressure dependent. The aim was to study local splanchnic circulatory effects and tissue oxygenation during intravenous infusion of Ang II at different levels of regional arterial driving pressure in a whole-body large animal model. METHODS: Ang II was infused in incremental doses (0-200 microg x h-1) in anaesthetised instrumented pigs (n=8). Mean superior mesenteric arterial pressure (PSMA) was adjusted by a local variable perivascular occluder. Perivascular ultrasound and laser-Doppler flowmetry were used for measurements of mesenteric venous blood flow and superficial intestinal blood flow, respectively. Intestinal oxygenation was evaluated by oxygen tissue tension (PtiO2) and lactate fluxes. RESULTS: Ang II produced prominent and dose-dependent increases in mesenteric vascular resistance (RSMA) when the intestine was exposed to systemic arterial pressure, but Ang II increased RSMA only minimally when PSMA was artificially kept constant at a lower level (50 mmHg) by the occluder. Although Ang II decreased PtiO2 at a PSMA of 50 mmHg, splanchnic lactate production was not observed. CONCLUSION: We demonstrate that splanchnic vasoconstriction by exogenous Ang II is dependent on arterial driving pressure, suggesting significant potentiation through autoregulatory increases in vasomotor tone. Intestinal hypoxaemia does not seem to occur during short-term infusion of Ang II in doses that significantly increases systemic arterial pressure.

sted, utgiver, år, opplag, sider
2002. Vol. 46, nr 1, s. 57-63
Emneord [en]
Angiotensin II/*pharmacology, Animals, Blood Pressure/*physiology, Female, Hemodynamics/drug effects, Jejunum/blood supply/metabolism, Laser-Doppler Flowmetry, Mesenteric Artery, Superior/physiology, Mesenteric Veins/physiology, Oxygen/metabolism, Oxygen Consumption, Splanchnic Circulation/drug effects/*physiology, Swine, Vascular Resistance/drug effects, Vasoconstriction/drug effects/*physiology, Vasoconstrictor Agents/*pharmacology
Identifikatorer
URN: urn:nbn:se:umu:diva-31417ISBN: 0001-5172 (Print) (tryckt)OAI: oai:DiVA.org:umu-31417DiVA, id: diva2:292969
Merknad
Broome, M Aneman, A Lehtipalo, S Arnerlov, C Johansson, G Winso, O Biber, B Research Support, Non-U.S. Gov't Denmark Acta anaesthesiologica Scandinavica Acta Anaesthesiol Scand. 2002 Jan;46(1):57-63.Tilgjengelig fra: 2010-02-10 Laget: 2010-02-10 Sist oppdatert: 2023-05-02

Open Access i DiVA

Fulltekst mangler i DiVA

Andre lenker

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11903073

Person

Lehtipalo, StefanJohansson, GöranWinsö, Ola

Søk i DiVA

Av forfatter/redaktør
Lehtipalo, StefanJohansson, GöranWinsö, Ola
Av organisasjonen

Søk utenfor DiVA

GoogleGoogle Scholar

isbn
urn-nbn

Altmetric

isbn
urn-nbn
Totalt: 359 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf