A novel stroke locus identified in a northern Sweden pedigree: linkage to chromosome 9q31-33.Visa övriga samt affilieringar
2009 (Engelska)Ingår i: Neurology, ISSN 0028-3878, E-ISSN 1526-632X, Vol. 73, nr 21, s. 1767-1773Artikel i tidskrift (Refereegranskat) Published
Abstract [en]
OBJECTIVES: The population of northern Sweden is characterized by reduced genetic diversity and a high incidence of stroke. We sought to reduce genetic variation further, using genealogic analysis in a set of nuclear families affected by stroke, and we subsequently performed a genome-wide scan to identify novel stroke susceptibility loci. METHODS: Through genealogy, 7 nuclear families with a common ancestor, connected over 8 generations, were identified. A genome-wide scan using 449 microsatellite markers was performed with subsequent haplotype analyses. RESULTS: A maximum allele-sharing lod score of 4.81 on chromosome 9q31-q33 was detected. Haplotype analysis identified a common 2.2-megabase interval in the chromosomal region in 4 of the nuclear families, where an overrepresentation of intracerebral hemorrhage was observed. CONCLUSIONS: We have identified a novel susceptibility locus for stroke. Haplotype analysis suggests that a shared genetic factor is of particular importance for intracerebral hemorrhage.
Ort, förlag, år, upplaga, sidor
2009. Vol. 73, nr 21, s. 1767-1773
Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
URN: urn:nbn:se:umu:diva-32341DOI: 10.1212/WNL.0b013e3181c34b1dPubMedID: 19933978Scopus ID: 2-s2.0-73349101853OAI: oai:DiVA.org:umu-32341DiVA, id: diva2:302866
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