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Regional differences in olfactory epithelial homeostasis in the adult mouse
Umeå universitet, Teknisk-naturvetenskaplig fakultet, Molekylärbiologi (Teknisk-naturvetenskaplig fakultet). (Berghard)
Umeå universitet, Teknisk-naturvetenskaplig fakultet, Molekylärbiologi (Teknisk-naturvetenskaplig fakultet). (Berghard)
Umeå universitet, Medicinsk fakultet, Molekylärbiologi (Medicinska fakulteten). (Bohm)
Umeå universitet, Teknisk-naturvetenskaplig fakultet, Molekylärbiologi (Teknisk-naturvetenskaplig fakultet). (Berghard)
2009 (Engelska)Ingår i: Journal of Comparative Neurology, ISSN 0021-9967, E-ISSN 1096-9861, Vol. 513, nr 4, s. 375-384Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

The olfactory sensory neurons in the nasal cavity of the adult mouse are organized into a few regions that differ in their molecular properties, as several classes of genes show regional expression. Most renowned is the fact that expression of each of hundreds of different odorant receptor genes is limited to one such region, or zone, of the olfactory neuroepithelial sheet. Zone differences are in place at birth, as exemplified here by the expression of neuronal progenitor marker Foxg1. We herein describe that an adult pattern showing regional differences in neurogenesis develops during the first few weeks of postnatal life which, e.g., is reflected in the temporal and regional regulation of the neuronal progenitor marker Ascl1. The most dorsomedial zone shows significantly fewer cells in S-phase in the adult but not in newborn mice by two different measures. Moreover, we show that there are regional differences in the relative differentiation, cell survival, and thickness of the olfactory epithelium. These findings are compatible with the view that zones are inherently distinct and that such differences contribute to generate regional differences in cellular homeostasis that in turn may modulate the capacity of a region to adjust to extrinsic influence.

Ort, förlag, år, upplaga, sidor
2009. Vol. 513, nr 4, s. 375-384
Nyckelord [en]
olfaction, neurogenesis, proliferation, zone, postnatal
Nationell ämneskategori
Cell- och molekylärbiologi
Identifikatorer
URN: urn:nbn:se:umu:diva-32741DOI: 10.1002/cne.21973PubMedID: 19177519OAI: oai:DiVA.org:umu-32741DiVA, id: diva2:305425
Tillgänglig från: 2010-03-23 Skapad: 2010-03-23 Senast uppdaterad: 2018-06-08Bibliografiskt granskad

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Vedin, ViktoriaBohm, StaffanBerghard, Anna

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Molekylärbiologi (Teknisk-naturvetenskaplig fakultet)Molekylärbiologi (Medicinska fakulteten)
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