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c-Met expression in primary tumors and their corresponding distant metastases
Umeå universitet, Medicinska fakulteten, Institutionen för medicinsk biovetenskap, Patologi.
Umeå universitet, Medicinska fakulteten, Institutionen för medicinsk biovetenskap, Patologi.
Umeå universitet, Medicinska fakulteten, Institutionen för medicinsk biovetenskap, Patologi.
Umeå universitet, Medicinska fakulteten, Institutionen för medicinsk biovetenskap, Patologi.
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2009 (Engelska)Ingår i: Molecular Medicine Reports, ISSN 1791-2997, Vol. 1, nr 6, s. 787-790Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

c-Met is a receptor tyrosine kinase that has beenimplicated in the pathogenesis and growth of a wide variety ofhuman malignancies, including CRC, but its role in metastasisis largely unknown. We compared c-Met expression in primaryhuman colorectal carcinomas and distant metastases from thesame patients. Formalin-fixed paraffin-embedded tissuesamples from 69 colorectal cancer patients were obtained. Theprotein expression of c-Met was evaluated immunohistochemicallyusing a commercial antibody. The difference inexpression between primary tumors and their correspondingdistant metastases was analyzed using the Wilcoxon signedranktest. c-Met expression was statistically significantlylower in the distant metastases compared to their correspondingprimary tumors (p<0.001), whereas no difference was foundbetween lymph node metastases and their correspondingprimary tumors (p=0.957). The degree of c-Met expressionwas not related to clinicopathological characteristics such astumor grade and Dukes' stage at the time of primary tumordiagnosis, or to the location of the distant metastases. Wedemonstrated that c-Met expression is often reduced in distantmetastases compared to their corresponding primary colorectaltumors. Additional studies of c-Met activation and signaltransduction will increase our knowledge about the role ofc-Met in colorectal cancer metastasis.

Ort, förlag, år, upplaga, sidor
Umeå, 2009. Vol. 1, nr 6, s. 787-790
Nyckelord [en]
c-Met, colorectal cancer, metastasis
Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
URN: urn:nbn:se:umu:diva-33121DOI: 10.3892/mmr_00000029OAI: oai:DiVA.org:umu-33121DiVA, id: diva2:310162
Tillgänglig från: 2010-04-13 Skapad: 2010-04-13 Senast uppdaterad: 2018-06-08Bibliografiskt granskad

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Van Guelpen, BethanyStenling, RogerPalmqvist, RichardHenriksson, Maria L

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