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Metabolic syndrome and endometrial carcinoma
Umeå universitet, Medicinska fakulteten, Institutionen för kirurgisk och perioperativ vetenskap, Urologi och andrologi.
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2010 (Engelska)Ingår i: American Journal of Epidemiology, ISSN 0002-9262, E-ISSN 1476-6256, Vol. 171, nr 8, s. 892-902Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

The authors examined the association between the metabolic syndrome and risk of incident endometrial and fatal uterine corpus cancer within a large prospective cohort study. Approximately 290,000 women from Austria, Norway, and Sweden were enrolled during 1974-2005, with measurements of height, weight, systolic and diastolic blood pressure, and circulating levels of glucose, total cholesterol, and triglycerides. Relative risks were estimated using Cox proportional hazards regression. The metabolic syndrome was assessed as a composite z score, as the standardized sum of z scores for body mass index, blood pressure, glucose, cholesterol, and triglycerides. A total of 917 endometrial carcinomas and 129 fatal cancers were identified. Increased risks of incident endometrial carcinoma and fatal uterine corpus cancer were seen for the metabolic syndrome factors combined, as well as for individual factors (except for cholesterol). The relative risk of endometrial carcinoma for the metabolic syndrome was 1.37 (95% confidence interval: 1.28, 1.46) per 1-unit increment of z score. The positive associations between metabolic syndrome factors (both individually and combined) and endometrial carcinoma were confined to the heaviest women. The association between the metabolic syndrome and endometrial carcinoma risk seems to go beyond the risk conferred by obesity alone, particularly in women with a high body mass index.

Ort, förlag, år, upplaga, sidor
2010. Vol. 171, nr 8, s. 892-902
Nyckelord [en]
adult, blood glucose/analysis, breast neoplasms/epidemiology/etiology/prevention & control, colorectal neoplasms/epidemiology/etiology/prevention & control, developed countries, emigrants and immigrants, female, humans, incidence, insulin resistance, life style, male, metabolic syndrome X/complications, neoplasms/epidemiology/etiology/*prevention & control, obesity/complications, overweight/complications, prostatic neoplasms/epidemiology/etiology/prevention & control, risk factors, Sweden/epidemiology, world health, cohort studies, endometrial neoplasm
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Medicin och hälsovetenskap
Identifikatorer
URN: urn:nbn:se:umu:diva-33270DOI: 10.1093/aje/kwq006ISI: 000277078300006PubMedID: 20219764OAI: oai:DiVA.org:umu-33270DiVA, id: diva2:311162
Tillgänglig från: 2010-04-20 Skapad: 2010-04-20 Senast uppdaterad: 2018-06-08Bibliografiskt granskad

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Stocks, TanjaHallmans, GöranJonsson, HåkanStattin, Pär

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Urologi och andrologiInstitutionen för folkhälsa och klinisk medicinNäringsforskningOnkologi
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