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Superoxide dismutase in amyotrophic lateral sclerosis patients homozygous for the D90A mutation
Umeå universitet, Medicinska fakulteten, Institutionen för medicinsk biovetenskap, Klinisk kemi.
Umeå universitet, Medicinska fakulteten, Institutionen för medicinsk biovetenskap, Patologi.
Umeå universitet, Medicinska fakulteten, Institutionen för farmakologi och klinisk neurovetenskap, Neurologi.
Umeå universitet, Medicinska fakulteten, Institutionen för medicinsk biovetenskap, Klinisk kemi.
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2009 (engelsk)Inngår i: Neurobiology of Disease, ISSN 0969-9961, E-ISSN 1095-953X, Vol. 36, nr 3, s. 421-424Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

The most common of the amyotrophic lateral sclerosis (ALS)-associated superoxide dismutase-1 (SOD1) mutations, D90A, differs from others in its high structural stability and by the existence of both recessive and dominant inheritance. Here SOD1 in CNS and peripheral organs from five ALS patients homozygous for D90A were compared to controls. In most areas, including ventral horns, there were no significant differences in SOD1 activities and Western blotting patterns between controls and D90A cases. The SOD1 activities in areas vulnerable to mutant SOD1s, ventral horns and precentral gyrus were intermediate among CNS areas and much lower than in kidney and liver. Thus, the vulnerability of motor areas is not explained by high SOD1 content. The findings argue against the idea of expression-reducing protective factors being present near the D90A locus in recessive pedigrees. The similarity to wild-type SOD1 prompts speculations on the involvement of the latter in sporadic ALS.

sted, utgiver, år, opplag, sider
2009. Vol. 36, nr 3, s. 421-424
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URN: urn:nbn:se:umu:diva-34682DOI: 10.1016/j.nbd.2009.08.006ISI: 000271689400002PubMedID: 19703565OAI: oai:DiVA.org:umu-34682DiVA, id: diva2:323794
Tilgjengelig fra: 2010-06-11 Laget: 2010-06-11 Sist oppdatert: 2018-06-08bibliografisk kontrollert

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