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Intestinal flora in very low-birth weight infants
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Pediatrik.
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Pediatrik.
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk mikrobiologi, Klinisk bakteriologi.
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2009 (Engelska)Ingår i: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 98, nr 11, s. 1762-1767Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

AIM: To study the early faecal microbiota in very low-birth weight infants (VLBW, <1500 g), possible associations between faecal microbiota and faecal calprotectin (f-calprotectin) and to describe the faecal microbiota in cases with necrotizing enterocolitis (NEC) before diagnosis. METHODS: Stool samples from the first weeks of life were analysed in 48 VLBW infants. Bacterial cultures were performed and f-calprotectin concentrations were measured. In three NEC cases, cultures were performed on stool samples obtained before diagnosis. RESULTS: Bifidobacteria and lactobacilli were often identified in the first stool sample, 55% and 71% of cases, respectively within the first week of life. A positive correlation between lactic acid bacteria (LAB) and volume of enteral feed was found. Other bacteria often identified were Escherichia coli, Enterococcus and Staphyloccus sp. F-calprotectin was not associated with any bacterial species. All NEC cases had an early colonization of LAB. Prior to onset of disease, all cases had a high colonization of non-E. coli Gram-negative species. CONCLUSION: In contrast to the previous studies in VLBW infants, we found an early colonization with LAB. We speculate that this may be due to early feeding of non-pasteurized breast milk.

Ort, förlag, år, upplaga, sidor
2009. Vol. 98, nr 11, s. 1762-1767
Nyckelord [en]
feacal calprotectin, infant, intestinal flora, ecrotizing enterocolitis, very low-birth weight
Identifikatorer
URN: urn:nbn:se:umu:diva-34996DOI: 10.1111/j.1651-2227.2009.01471.xPubMedID: 19673724OAI: oai:DiVA.org:umu-34996DiVA, id: diva2:327475
Tillgänglig från: 2010-06-29 Skapad: 2010-06-29 Senast uppdaterad: 2018-06-08Bibliografiskt granskad

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Håkansson, StellanDomellöf, Magnus

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