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Temporal reliability of cytokines and growth factors in EDTA plasma
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Obstetrik och gynekologi.
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2010 (Engelska)Ingår i: BMC research notes, ISSN 1756-0500, Vol. 3, nr 1, s. 302-Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

BACKGROUND: Cytokines are involved in the development of chronic diseases, including cancer. It is important to evaluate the temporal reproducibility of cytokines in plasma prior to conducting epidemiologic studies utilizing these markers.

FINDINGS: We assessed the temporal reliability of CRP, 22 cytokines and their soluble receptors (IL-1alpha, IL-1beta, IL-1Ra, IL-2, sIL-2R, IL-4, IL-5, IL-6, sIL-6R, IL-7, IL-8, IL-10, IL-12p40, IL-12p70, IL-13, IL-15, IL-17, TNFalpha, sTNF-R1, sTNF-R2, IFNalpha, IFNgamma) and eight growth factors (GM-CSF, EGF, bFGF, G-CSF, HGF, VEGF, EGFR, ErbB2) in repeated EDTA plasma samples collected an average of two years apart from 18 healthy women (age range: 42-62) enrolled in a prospective cohort study. We also estimated the correlation between serum and plasma biomarker levels using 18 paired clinical samples from postmenopausal women (age range: 75-86). Twenty-six assays were able to detect their analytes in at least 70% of samples. Of those 26 assays, we observed moderate to high intra-class correlation coefficients (ICCs)(ranging from 0.53-0.89) for 22 assays, and low ICCs (0-0.47) for four assays. Serum and plasma levels were highly correlated (r > 0.6) for most markers, except for seven assays (r < 0.5).

CONCLUSIONS: For 22 of the 31 biomarkers, a single plasma measurement is a reliable estimate of a woman's average level over a two-year period.

Ort, förlag, år, upplaga, sidor
2010. Vol. 3, nr 1, s. 302-
Nationell ämneskategori
Medicin och hälsovetenskap
Forskningsämne
patologi
Identifikatorer
URN: urn:nbn:se:umu:diva-38091DOI: 10.1186/1756-0500-3-302PubMedID: 21073739OAI: oai:DiVA.org:umu-38091DiVA, id: diva2:372247
Tillgänglig från: 2010-11-24 Skapad: 2010-11-24 Senast uppdaterad: 2018-06-08Bibliografiskt granskad

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Idahl, AnnikaHallmans, GöranOhlson, NinaLundin, Eva

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