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Season of birth and multiple sclerosis in Sweden
Umeå universitet, Medicinska fakulteten, Institutionen för farmakologi och klinisk neurovetenskap, Neurologi.
Umeå universitet, Medicinska fakulteten, Institutionen för farmakologi och klinisk neurovetenskap, Neurologi.
Umeå universitet, Medicinska fakulteten, Institutionen för farmakologi och klinisk neurovetenskap, Neurologi.
2010 (Engelska)Ingår i: Acta Neurologica Scandinavica, ISSN 0001-6314, E-ISSN 1600-0404, Vol. 122, nr 1, s. 70-73Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

This study supports previous results suggesting an association between the risk of MS and the season of birth. Decreased exposure to sun in the winter leading to low vitamin D levels during pregnancy is a possible explanation that needs further research.

Ort, förlag, år, upplaga, sidor
2010. Vol. 122, nr 1, s. 70-73
Nyckelord [en]
epidemiology; etiology; month of birth; multiple sclerosis; season of birth; seasonality; vitamin D
Nationell ämneskategori
Neurologi
Forskningsämne
neurologi
Identifikatorer
URN: urn:nbn:se:umu:diva-42291DOI: 10.1111/j.1600-0404.2010.01396.xPubMedID: 20597868OAI: oai:DiVA.org:umu-42291DiVA, id: diva2:409078
Tillgänglig från: 2012-11-09 Skapad: 2011-04-07 Senast uppdaterad: 2018-06-08Bibliografiskt granskad
Ingår i avhandling
1. Environmental risk factors for multiple sclerosis
Öppna denna publikation i ny flik eller fönster >>Environmental risk factors for multiple sclerosis
2013 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Alternativ titel[sv]
Miljöfaktorers betydelse för multipel skleros
Abstract [en]

Background Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system. It usually strikes during young adulthood, and 2.5 million individuals are estimated to have the disease worldwide. The causes of MS are not known, but several factors have been shown to be associated with the risk of the disease, including certain genes, vitamin D, smoking and Epstein- Barr virus infection. Little is known about how/if these factors interact.

Methods Study I: The risk of MS by month of birth was investigated using MS cases from the Swedish MS registry and using general population controls. Studies II–V: We identified MS cases who had donated blood prior to disease onset, and MS cases whose mothers had donated blood during pregnancy, by cross-linking a database of MS cases, and a database of mothers of MS cases, to two local biobank cohorts. One of them consisted of blood samples collected during early pregnancy, and one with samples collected during health controls. Levels of 25(OH)D (25-hydroxyvitamin D), RBP (retinol binding protein, a surrogate marker for vitamin A), CRP (C- reactive protein), cotinine (a nicotine metabolite) and anti Epstein-Barr virus nuclear antigen-1 (EBNA-1) antibodies were measured in cases and matched controls. The risk of MS by categories of these exposures was estimated in bi- and multivariable matched logistic regression models.

Results Subjects born in spring had a higher risk of MS, but no influence of early gestational levels of the measured risk factors on the risk of MS in the offspring was observed. In prospective samples from MS cases and controls, 25(OH)D levels ≥75 nmol/l, intermediate RBP levels, and elevated CRP levels in young were associated with a decreased risk of MS. Elevated cotinine levels (suggestive of smoking) and high antibody reactivity against EBNA-1 were associated with an increased risk of MS. All factors but RBP were more clearly associated with MS in young subjects.

Conclusion All factors analyzed in prospectively collected samples were associated with the risk of MS, and taken together, the data indicate that the key etiopathological events that lead to MS occur before the age of 20–30. Study II provides support for trials exploring the primary preventive potential of oral vitamin D supplementation.

Ort, förlag, år, upplaga, sidor
Umeå: Umeå Universitet, 2013. s. 54
Serie
Umeå University medical dissertations, ISSN 0346-6612 ; 1545
Nyckelord
Multiple sclerosis, risk factors in epidemiology, prospective, month of birth, vitamin D, vitamin A, C-reactive protein, hygiene hypothesis, smoking, cotinine, Epstein-Barr virus
Nationell ämneskategori
Neurologi
Forskningsämne
epidemiologi
Identifikatorer
urn:nbn:se:umu:diva-64212 (URN)978-91-7459-545-1 (ISBN)
Disputation
2013-03-01, Hörsal E04, By 6E, Norrlands Universitetssjukhus, Umeå, 09:00 (Svenska)
Opponent
Handledare
Tillgänglig från: 2013-02-08 Skapad: 2013-01-21 Senast uppdaterad: 2018-06-08Bibliografiskt granskad

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Salzer, JonatanSvenningsson, AndersSundström, Peter

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