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In vivo skin measurements with a novel probe head for simultaneous skin impedance and near-infrared spectroscopy
Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen. Umeå universitet, Medicinska fakulteten, Institutionen för kirurgisk och perioperativ vetenskap, Kirurgi. Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Centrum för medicinsk teknik och fysik (CMTF).
Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen.
Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen.
Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen.
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2011 (Engelska)Ingår i: Skin research and technology, ISSN 0909-752X, E-ISSN 1600-0846, Vol. 17, nr 4, s. 494-504Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background/purpose: Near-infrared (NIR) spectroscopy and skin impedance (IMP) measurements are useful techniques for objective diagnostics of various skin diseases. Here, we present a combined probe head for simultaneous, time-saving NIR spectroscopy and skin impedance measurements. The probe also ensures that both measurements are performed under equal conditions and at the same skin location.

Methods: Finite element method simulations were performed for evaluation of the impedance. In vivo skin measurements were performed and combined NIR and impedance spectra were analysed by means of multivariate methods with respect to body location, age and gender. The classification rate was determined by a planar discriminant analysis. Reproducibility was investigated by calculation of scatter values and statistical significance between overlapping groups was assessed by the calculation of intra-model distances, q.

Results: The novel probe yielded rapid reproducible results and was easy to manage. Significant differences between skin locations and to a lesser extent age groups and gender were demonstrated.

Conclusion: With the novel probe, statistically significant differences between overlapping classes in score plots can be confirmed by calculating intra-model distances. The influence of molecular differences in the skin at different body locations is larger than the influence of gender or age and therefore relevant reference measurements are discussed.

Ort, förlag, år, upplaga, sidor
Wiley , 2011. Vol. 17, nr 4, s. 494-504
Nyckelord [en]
near-infrared spectroscopy, skin impedance, probe development, PCA, PLS-DA, in vivo skin measurement, non-invasive, age, gender, skin characteristics
Nationell ämneskategori
Dermatologi och venereologi Biomedicinsk laboratorievetenskap/teknologi
Identifikatorer
URN: urn:nbn:se:umu:diva-45029DOI: 10.1111/j.1600-0846.2011.00524.xPubMedID: 21492242OAI: oai:DiVA.org:umu-45029DiVA, id: diva2:425787
Tillgänglig från: 2011-06-22 Skapad: 2011-06-20 Senast uppdaterad: 2018-06-08Bibliografiskt granskad
Ingår i avhandling
1. Near infrared and skin impedance spectroscopic in vivo measurements on human skin: development of a diagnostic tool for skin cancer
Öppna denna publikation i ny flik eller fönster >>Near infrared and skin impedance spectroscopic in vivo measurements on human skin: development of a diagnostic tool for skin cancer
2011 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Abstract [en]

Every year approximately 2800 Swedes are diagnosed with malignant melanoma, the form of cancer that is most rapidly increasing in incidence in the Western world. The earlier we can identify and diagnose a malignant melanoma, the better is the prognosis. In Sweden, 155 000 benign naevi, harmless skin tumours or moles, are surgically excised each year, many of them because melanoma cannot be dismissed by non-invasive methods. The excisions result in substantial medical costs and cause unrest and suffering of the individual patient. For untrained physicians, it is often difficult to make an accurate diagnosis of melanoma, thus a tool that could help to strengthen the diagnosis of suspected melanomas would be highly valuable. This thesis describes the development and assessment of a non-invasive method for early skin cancer detection. Using near infrared (NIR) and skin impedance spectroscopy, healthy and diseased skin of various subjects was examined to develop a new instrument for detecting malignant melanoma. Due to the complex nature of skin and the numerous variables involved, the spectroscopic data were analysed multivariately using Principal Component Analysis (PCA) and partial leas square discriminant analysis (PLS-DA). The reproducibility of the measurements was determined by calculating Scatter Values (SVs), and the significance of separations between overlapping groups in score plots was determined by calculating intra-model distances.

The studies indicate that combining skin impedance and NIR spectroscopy measurements adds value, therefore a new probe-head for simultaneous NIR and skin impedance measurements was introduced. Using both spectroscopic techniques it was possible to separate healthy skin at one body location from healthy skin at another location due to the differences in skin characteristics at various body locations. In addition, statistically significant differences between overlapping groups of both age and gender in score plots were detected. However, the differences in skin characteristics at different body locations had stronger effects on the measurements than both age and gender. Intake of coffee and alcohol prior to measurement did not significantly influence the outcome data. Measurements on dysplastic naevi were significantly separated in a score plot and the influence of diseased skin was stronger than that of body location. This was confirmed in a study where measurements were performed on 12 malignant melanomas, 19 dysplastic naevi and 19 benign naevi. The malignant melanomas were significantly separated from both dysplastic naevi and benign naevi.

Overall, the presented findings show that the instrument we have developed provides fast, reproducible measurements, capable of distinguishing malignant melanoma from dysplastic naevi and benign naevi non-invasively with 83% sensitivity and 95% specificity. Thus, the results are highly promising and the instrument appears to have high potential diagnostic utility.

Ort, förlag, år, upplaga, sidor
Umeå: Umeå universitet, 2011. s. 51
Serie
Umeå University medical dissertations, ISSN 0346-6612 ; 1466
Nyckelord
Combined probe head, Malignant melanoma, diagnosis, NIR, Skin impedance, PCA, PLS-DA
Nationell ämneskategori
Kirurgi
Forskningsämne
kirurgi
Identifikatorer
urn:nbn:se:umu:diva-50605 (URN)978-91-7459-335-8 (ISBN)
Disputation
2012-01-27, KB3A9, KBC, Umeå universitet, Umeå, 10:00 (Engelska)
Opponent
Handledare
Tillgänglig från: 2011-12-23 Skapad: 2011-12-15 Senast uppdaterad: 2018-06-08Bibliografiskt granskad

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Bodén, IdaLarsson, WilliamNilsson, DavidNaredi, PeterLindholm-Sethson, Britta

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Bodén, IdaLarsson, WilliamNilsson, DavidNaredi, PeterLindholm-Sethson, Britta
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Kemiska institutionenKirurgiCentrum för medicinsk teknik och fysik (CMTF)
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Skin research and technology
Dermatologi och venereologiBiomedicinsk laboratorievetenskap/teknologi

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