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Side-effects of post-treatment biopsies in prostate cancer patients treated with endocrine therapy alone or combined with radical radiotherapy in the Scandinavian Prostate Cancer Group-7 randomized trial
Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper, Onkologi.
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2011 (Engelska)Ingår i: Scandinavian Journal of Urology and Nephrology, ISSN 0036-5599, E-ISSN 1651-2065, Vol. 45, nr 4, s. 233-238Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Objective. Post-treatment prostate biopsy side-effects were evaluated in patients with locally advanced prostate cancer on endocrine therapy alone or combined with radiotherapy in the Scandinavian Prostate Cancer Group-7 randomized trial.

Material and methods. One-hundred and twenty patients underwent transrectalultrasound-guided biopsy, and were requested to complete a questionnaire on side-effects occurring within 7 days' follow-up.

Results. The questionnaire was returned by 109 patients (91%) (endocrine therapy only 52%, combined endocrine therapy and radiotherapy 48%). Previous therapy had no significant influence on pain, urinary flow, haematuria or haematospermia. Pain at biopsy was reported in 63% (mild, 57%; moderate, 5.6%; severe, one patient) and pain at follow-up in 31% (mild, 27%; moderate, four patients). Haematuria (mean duration 2.2 days) was reported in 41%, and reduced urinary flow in 20% (mild, 18%; severe: four patients; no patient had urinary retention). Haematospermia was scarce. No patient reported urinary tract infection. Rectal bleeding occurred in 18% in the endocrine and 35% in the combined therapy group (p = 0.047), with a mean duration of 1.6 and 2.2 days, respectively (p = 0.031). In logistic regression analysis, a trend towards increased rectal bleeding was found in patients on combined endocrine therapy and radiotherapy (odds ratio 2.4, p = 0.050).

Conclusion. Patient-reported post-treatment prostate biopsy side-effects were mild and self-limiting.

Ort, förlag, år, upplaga, sidor
2011. Vol. 45, nr 4, s. 233-238
Nyckelord [en]
Endocrine therapy, post-treatment biopsy, prostate cancer, radiotherapy, side-effects
Identifikatorer
URN: urn:nbn:se:umu:diva-45825DOI: 10.3109/00365599.2011.560577PubMedID: 21452932OAI: oai:DiVA.org:umu-45825DiVA, id: diva2:435138
Tillgänglig från: 2011-08-17 Skapad: 2011-08-17 Senast uppdaterad: 2018-06-08Bibliografiskt granskad

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