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Gene Expression of Estrogen Receptors in Pbmc From Patients With Puumala-Virus Infection
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk mikrobiologi, Infektionssjukdomar.
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk mikrobiologi, Infektionssjukdomar. (Arcum)
Vise andre og tillknytning
2012 (engelsk)Inngår i: Shock, ISSN 1073-2322, E-ISSN 1540-0514, Vol. 37, nr 4, s. 355-359Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

The influence of estrogen signaling on infectious diseases is not fully known. Males seem to be more susceptible to infections than females. This has also been noted for the Scandinavian form of hemorrhagic fever with renal syndrome caused by Puumala hantavirus (PUUV). To investigate the differences in estrogen receptors in relation to sex and clinical severity, 20 patients (10 males, 10 females) with confirmed PUUV infection were studied. Real-time polymerase chain reaction was performed for analyzing mRNA expression of estrogen receptor-alpha (ERV), ER beta, and ER beta 2 (ER beta cx) in peripheral blood mononuclear cells from patients and healthy age-and sex-matched blood donors. Blood chemistry and peripheral blood mononuclear cells sampling were performed during the acute and convalescent phases. None or very small amounts of ER beta were detected, and ER alpha and ER beta 2 mRNA were elevated in the patient group. The samples from the males were correlated with ER beta 2; the female samples, with ER alpha. Furthermore, the female and male samples are partly separated using multivariate statistic analysis (principal component analysis), supporting findings that clinical symptoms differ depending on sex.

sted, utgiver, år, opplag, sider
Philadelphia: Lippincott Williams & Wilkins, 2012. Vol. 37, nr 4, s. 355-359
Emneord [en]
Sex differences, infectious diseases, hantavirus, HFRS, nephropathia epidemica, PCA
HSV kategori
Identifikatorer
URN: urn:nbn:se:umu:diva-54117DOI: 10.1097/SHK.0b013e31824ae41eISI: 000301681400004OAI: oai:DiVA.org:umu-54117DiVA, id: diva2:517368
Tilgjengelig fra: 2012-04-23 Laget: 2012-04-17 Sist oppdatert: 2018-06-08bibliografisk kontrollert

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