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The iImpact of Leptin and Adiponectin on incident type 2 Diabetes is modified by sex and insulin resistance
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Allmänmedicin. (Jämtland City Council, Res & Dev Unit, Östersund, Sweden)
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Allmänmedicin.
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Epidemiologi och global hälsa. (Arcum)ORCID-id: 0000-0003-2475-7131
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Kardiologi.
2012 (Engelska)Ingår i: Metabolic Syndrome and Related Disorders, ISSN 1540-4196, E-ISSN 1557-8518, Vol. 10, nr 2, s. 143-151Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: Adiponectin and leptin and their ratio have been associated with incident type 2 diabetes (T2DM), although the data presented are conflicting and the populations studied have been small. In this large, prospective, nested, case referent study, we hypothesized that these associations are sex specific and may be modified by insulin resistance. Methods: Men and women aged 30-60 years with incident T2DM (n = 640) and a prior health survey within the Vasterbotten Intervention Programme (VIP) and matched referents (n = 1564) were identified. Using conditional logistic regression analyses, we tested whether baseline plasma adiponectin and leptin levels and their ratio independently predicted incident T2DM, stratified for gender and insulin resistance. Results: Adjusted for traditional risk factors, fourth-quartile levels of adiponectin were associated with a reduced risk of T2DM in men [odds ratio (OR) 0.55 (0.36-0.86)] and women [OR 0.47 (0.27-0.83)]. Quartile four of the leptin/adiponectin ratio predicted T2DM in both men [OR 3.08 (1.68-5.67)] and women [OR 3.31 (1.56-7.03)], whereas quartile-four levels of leptin predicted T2DM only in men [OR 2.30 (1.32-4.02)]. When stratified for insulin sensitivity and adjusted for body mass index (BMI), loge-transformed leptin predicted T2DM in insulin-sensitive men [OR 1.56 (1.13-2.17)] but not in insulin-resistant men [OR 1.03 (0.76-1.39)]. The effect of adiponectin and the leptin/adiponectin ratio was not influenced by the insulin sensitivity status. Conclusions: Leptin in men and adiponectin in both sexes were independent predictors of T2DM. The association was modified by the degree of insulin sensitivity. The leptin/adiponectin ratio may add predictive information beyond the separate hormones.

Ort, förlag, år, upplaga, sidor
2012. Vol. 10, nr 2, s. 143-151
Nyckelord [en]
Metabolic syndrome, Risk, Association, Protein, Ratio, Men, Population, Adipokines, Protection, Mauritius
Nationell ämneskategori
Endokrinologi och diabetes
Identifikatorer
URN: urn:nbn:se:umu:diva-54324DOI: 10.1089/met.2011.0123ISI: 000301957500011OAI: oai:DiVA.org:umu-54324DiVA, id: diva2:523447
Tillgänglig från: 2012-04-24 Skapad: 2012-04-24 Senast uppdaterad: 2018-06-08Bibliografiskt granskad

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Lilja, MikaelRolandsson, OlovNorberg, MargaretaSöderberg, Stefan

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Lilja, MikaelRolandsson, OlovNorberg, MargaretaSöderberg, Stefan
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AllmänmedicinEpidemiologi och global hälsaKardiologi
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