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A combined tactile and Raman probe for tissue characterization - design considerations
Luleå University of Technology.
Luleå University of Technology and Chalmers University of Technology.
Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Institutionen för tillämpad fysik och elektronik. Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Centrum för medicinsk teknik och fysik (CMTF).
Luleå University of Technology.
Vise andre og tillknytning
2012 (engelsk)Inngår i: Measurement science and technology, ISSN 0957-0233, E-ISSN 1361-6501, Vol. 23, nr 6, s. 065901-Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Histopathology is the golden standard for cancer diagnosis and involves the characterization of tissue components. It is labour intensive and time consuming. We have earlier proposed a combined fibre-optic near-infrared Raman spectroscopy (NIR-RS) and tactile resonance method (TRM) probe for detecting positive surgical margins as a complement to interoperative histopathology. The aims of this study were to investigate the effects of attaching an RS probe inside a cylindrical TRM sensor and to investigate how laser-induced heating of the fibre-optic NIR-RS affected the temperature of the RS probe tip and an encasing TRM sensor. In addition, the possibility to perform fibre-optic NIR-RS in a well-lit environment was investigated. A small amount of rubber latex was preferable for attaching the thin RS probe inside the TRM sensor. The temperature rise of the TRM sensor due to a fibre-optic NIR-RS at 270 mW during 20 s was less than 2 °C. Fibre-optic NIR-RS was feasible in a dimmed bright environment using a small light shield and automatic subtraction of a pre-recorded contaminant spectrum. The results are promising for a combined probe for tissue characterization.

sted, utgiver, år, opplag, sider
Institute of Physics (IOP), 2012. Vol. 23, nr 6, s. 065901-
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URN: urn:nbn:se:umu:diva-55061DOI: 10.1088/0957-0233/23/6/065901OAI: oai:DiVA.org:umu-55061DiVA, id: diva2:525342
Tilgjengelig fra: 2012-05-07 Laget: 2012-05-07 Sist oppdatert: 2018-06-08bibliografisk kontrollert

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