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Small Molecule Screening for Inhibitors of the YopH Phosphatase of Yersinia pseudotuberculosis
Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen.
Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen. Umeå universitet, Medicinska fakulteten, Umeå Centre for Microbial Research (UCMR).
Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen. Umeå universitet, Medicinska fakulteten, Umeå Centre for Microbial Research (UCMR).
Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen. Umeå universitet, Medicinska fakulteten, Umeå Centre for Microbial Research (UCMR).
Vise andre og tillknytning
2012 (engelsk)Inngår i: Advances in Yersinia Research, New York: Springer, 2012, Vol. 954, s. 357-363Kapittel i bok, del av antologi (Fagfellevurdert)
Abstract [en]

Bacterial virulence systems are attractive targets for development of new antibacterial agents. Yersinia spp. utilize the type III secretion (T3S) system to secrete and translocate Yersinia outer proteins (Yop effectors) into the cytosol of the target cell and thereby overcome host defenses to successfully establish an infection. Thus, the Yop effectors constitute attractive targets for drug development. In the present study we apply small molecule screening to identify inhibitors of one of the secreted proteins YopH, a tyrosine phosphatase required for virulence. Characterization of seven inhibitors indicated that both competitive and noncompetitive inhibitors were identified with IC50 values of 6–20 μM.

sted, utgiver, år, opplag, sider
New York: Springer, 2012. Vol. 954, s. 357-363
Serie
Advances in experimental medicine and biology, ISSN 0065-2598 ; 954
HSV kategori
Identifikatorer
URN: urn:nbn:se:umu:diva-57956DOI: 10.1007/978-1-4614-3561-7_43ISI: 000333327900044PubMedID: 22782782ISBN: 978-1-4614-3560-0 (tryckt)ISBN: 978-1-4614-3561-7 (tryckt)OAI: oai:DiVA.org:umu-57956DiVA, id: diva2:546514
Tilgjengelig fra: 2012-08-23 Laget: 2012-08-21 Sist oppdatert: 2018-06-08bibliografisk kontrollert

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Eriksson, JonasGrundström, ChristinSauer-Eriksson, A ElisabethSauer, Uwe HWolf-Watz, HansElofsson, Mikael

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