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Mercury in serum predicts low risk of death and myocardial infarction in Gothenburg women
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Yrkes- och miljömedicin.
Department of Oral and Maxillofacial Radiology, The Sahlgrenska Academy, University of Gothenburg.
Department of Occupational and Environmental Medicine, The Sahlgrenska Academy, University of Gothenburg.
Department of Public Health and Community Medicine/Primary Health Care, The Sahlgrenska Academy, University of Gothenburg.
Vise andre og tillknytning
2013 (engelsk)Inngår i: International Archives of Occupational and Environmental Health, ISSN 0340-0131, E-ISSN 1432-1246, Vol. 86, nr 1, s. 71-77Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

PURPOSE: Markers of mercury (Hg) exposure have shown both positive and negative associations with cardiovascular disease (CVD). We assessed the association between serum Hg (S-Hg) and risk of cardiovascular disease in a prospective population-based cohort, with attention to the roles of dental health and fish consumption.

METHODS: Total mortality, as well as morbidity and mortality from acute myocardial infarction (AMI) and stroke, was followed up for 32 years in 1,391 women (initially age 38-60), in relation to S-Hg at baseline, using Cox regression models. Potential confounders (age, socioeconomic status, serum lipids, alcohol consumption, dental health, smoking, hypertension, waist-hip ratio, and diabetes) and other covariates (e.g., fish consumption) were also considered.

RESULTS: Hazard ratios (HR) adjusted only for age showed strong inverse associations between baseline S-Hg and total mortality [highest quartile: hazard ratio (HR) 0.76; 95% confidence interval (CI) 0.59-0.97], incident AMI (HR 0.56; CI 0.34-0.93), and fatal AMI (HR 0.31; CI 0.15-0.66). Adjustment for potential confounding factors, especially dental health, had a strong impact on the risk estimates, and after adjustment, only the reduced risk of fatal AMI remained statistically significant.

CONCLUSIONS: There was a strong inverse association between Hg exposure and CVD. Likely, reasons are confounding with good dental health (also correlated with the number of amalgam fillings in these age groups) and/or fish consumption. The results suggest potential effects of dental health and/or fish consumption on CVD that deserve attention in preventive medicine.

sted, utgiver, år, opplag, sider
Springer, 2013. Vol. 86, nr 1, s. 71-77
Emneord [en]
mercury, fish, amalgam, mortality, cardiovascular, myocardial infarction, stroke
HSV kategori
Identifikatorer
URN: urn:nbn:se:umu:diva-62273DOI: 10.1007/s00420-012-0746-8ISI: 000313012900009PubMedID: 22350276OAI: oai:DiVA.org:umu-62273DiVA, id: diva2:576933
Tilgjengelig fra: 2012-12-14 Laget: 2012-12-14 Sist oppdatert: 2018-06-08bibliografisk kontrollert

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Bergdahl, Ingvar A.Wennberg, Maria

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