Umeå University's logo

umu.sePublikasjoner
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Microdialysis in early detection of temporary pancreatic ischemia in a porcine model
Umeå universitet, Medicinska fakulteten, Institutionen för kirurgisk och perioperativ vetenskap, Anestesiologi och intensivvård.
Umeå universitet, Medicinska fakulteten, Institutionen för medicinsk biovetenskap, Patologi.
Umeå universitet, Medicinska fakulteten, Institutionen för kirurgisk och perioperativ vetenskap, Anestesiologi och intensivvård.
Vise andre og tillknytning
2012 (engelsk)Inngår i: European Surgical Research, ISSN 0014-312X, E-ISSN 1421-9921, Vol. 49, nr 3-4, s. 113-120Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background: Ischemic injury to the pancreas occurs in various clinical conditions. A method for online monitoring of pathophysiological events in pancreatic parenchyma is missing. Aims: To assess the timing of microdialysis (MD) technique response on temporary changes in pancreatic perfusion, and to evaluate the relationship between MD data and systemic markers of anaerobic metabolism and inflammation. Methods: In anaesthetized normoventilated pigs, MD probes were placed in right (control) and left (ischemic) pancreatic lobes, respectively. Following the clamping of the vessels, ischemia was verified by tissue oxygen tension (PtiO2) measurements. Results: PtiO2 decreased within 20 min after the clamping of the vessels, already returning to baseline levels at the first sampling point after the removal of the clamp. MD lactate levels increased, whereas pyruvate and glucose levels decreased at 20 min after the induction of ischemia. These trends continued until the end of ischemia and returned to baseline following reperfusion. Serum lactate, amylase and tumor necrosis factor-alpha levels decreased throughout the protocol time. Conclusion: MD data were in concordance with changes in PtiO2, which is indicative of local anaerobic metabolism. MD allowed the detection of pathophysiological processes within the ischemic pancreas at a stage when no elevations of systemic markers of ischemia or inflammation were observed.

sted, utgiver, år, opplag, sider
2012. Vol. 49, nr 3-4, s. 113-120
Emneord [en]
Experimental model, Ischemia, Microdialysis, Pancreas, Pig
HSV kategori
Identifikatorer
URN: urn:nbn:se:umu:diva-63611DOI: 10.1159/000343806Scopus ID: 2-s2.0-84871559250OAI: oai:DiVA.org:umu-63611DiVA, id: diva2:583656
Tilgjengelig fra: 2013-01-08 Laget: 2013-01-03 Sist oppdatert: 2023-05-02bibliografisk kontrollert

Open Access i DiVA

Fulltekst mangler i DiVA

Andre lenker

Forlagets fulltekstScopus

Person

Kral, JosefWang, WanzhongKralova, IvanaAbrahamsson, PernillaJohansson, GöranWinsö, Ola

Søk i DiVA

Av forfatter/redaktør
Kral, JosefWang, WanzhongKralova, IvanaAbrahamsson, PernillaJohansson, GöranWinsö, Ola
Av organisasjonen
I samme tidsskrift
European Surgical Research

Søk utenfor DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric

doi
urn-nbn
Totalt: 764 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf