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Metabolic factors associated with risk of renal cell carcinoma
Umeå universitet, Medicinska fakulteten, Institutionen för kirurgisk och perioperativ vetenskap, Urologi och andrologi.
Univ Ulm, Inst Epidemiol & Med Biometry, D-89069 Ulm, Germany.
Umeå universitet, Medicinska fakulteten, Institutionen för kirurgisk och perioperativ vetenskap, Urologi och andrologi.
Lund Univ, Skåne Univ Hosp, Dept Surg, Malmö, Sweden.
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2013 (Engelska)Ingår i: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 8, nr 2, s. e57475-Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Previous studies have shown that obesity and hypertension are associated with increased risk of renal cell carcinoma (RCC), but less is known about the association to other metabolic factors. In the Metabolic Syndrome and Cancer project (Me-Can) data on body mass index (BMI, kg/m2), blood pressure, and circulating levels of glucose, cholesterol, and triglycerides were collected from 560,388 men and women in cohorts from Norway, Austria, and Sweden. By use of Cox proportional hazard models, hazard ratios (HR) were calculated for separate and composite metabolic exposures. During a median follow-up of 10 years, 592 men and 263 women were diagnosed with RCC. Among men, we found an increased risk of RCC for BMI, highest vs. lowest quintile, (HR = 1.51, 95% CI 1.13-2.03), systolic blood pressure, (HR = 3.40, 95% CI 1.91-6.06), diastolic blood pressure, (HR = 3.33, 95% CI 1.85-5.99), glucose, (HR = 3.75, 95% CI 1.46-9.68), triglycerides, (HR = 1.79, 95% CI 1.00-3.21) and a composite score of these metabolic factors, (HR = 2.68, 95% CI 1.75-4.11). Among women we found an increased risk of RCC for BMI, highest vs. lowest quintile, (HR = 2.21, 95% CI 1.32-3.70) and the composite score, (HR = 2.29, 95% CI 1.12-4.68). High levels of the composite score were also associated with risk of death from RCC among both men and women. No multiplicative statistical or biological interactions between metabolic factors on risk of RCC were found. High levels of BMI, blood pressure, glucose and triglycerides among men and high BMI among women were associated with increased risk of RCC.

Ort, förlag, år, upplaga, sidor
2013. Vol. 8, nr 2, s. e57475-
Nationell ämneskategori
Urologi och njurmedicin
Identifikatorer
URN: urn:nbn:se:umu:diva-67967DOI: 10.1371/journal.pone.0057475ISI: 000315524900094OAI: oai:DiVA.org:umu-67967DiVA, id: diva2:615683
Anmärkning

Finansiär: Lion’s Cancer Research Foundation, Umeå University, Sweden (LP 09-1799)

Tillgänglig från: 2013-04-11 Skapad: 2013-04-09 Senast uppdaterad: 2018-06-08Bibliografiskt granskad
Ingår i avhandling
1. Metabolic factors and risk of prostate, kidney, and bladder cancer
Öppna denna publikation i ny flik eller fönster >>Metabolic factors and risk of prostate, kidney, and bladder cancer
2013 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Abstract [en]

Background: Prostate cancer is the most common cancer in Sweden with around 10,000 new cases every year. Kidney and bladder cancer are less common with 1,000 and 2,000 new cases annually, respectively. The incidence of these cancer sites is higher in developed, than in developing countries, suggesting an association between lifestyle and cancer risk. The aims of this thesis were to investigate body mass index (BMI), blood pressure, and blood levels of glucose, total cholesterol, and triglycerides as risk factors for prostate, kidney, and bladder cancer. Furthermore, we aimed at assess probabilities of prostate cancer and competing events, all-cause death, for men with normal and high levels of metabolic factors.

Material and methods: This thesis was conducted within the Metabolic Syndrome and Cancer project (Me-Can), a pooled cohort study with data from 578,700 participants from Norway, Sweden, and Austria. Data from metabolic factors were prospectively collected at health examinations and linked to the Cancer and Cause of Death registers in each country. 

Results: High levels of metabolic factors were not associated with increased risk of prostate cancer, but high levels of BMI and blood pressure were associated with risk of prostate cancer death. The probability of prostate cancer was higher for men with normal levels of metabolic factors compared to men with high levels, but the probability of all-cause death, was higher for men with high levels than for those with normal levels. For both men and women, high levels of metabolic factors were associated with increased risk of kidney cancer (renal cell carcinoma). Furthermore, blood pressure for men and BMI for women were found as independent risk factors of kidney cancer. High blood pressure was associated with an increased risk of bladder cancer for men.

Conclusions: High levels of metabolic factors were associated to risk of kidney and bladder cancer and to death from kidney, bladder, and prostate cancer. Compared to men with normal levels, men with high levels of metabolic factors had a decreased probability of prostate cancer but an increased probability of all-cause death.

Ort, förlag, år, upplaga, sidor
Umeå: Umeå Universitet, 2013. s. 58
Serie
Umeå University medical dissertations, ISSN 0346-6612 ; 1612
Nyckelord
cohort study, competing risk, epidemiology, metabolic factors, prostate cancer, kidney cancer, bladder cancer, renal cell carcinoma, survival analysis
Nationell ämneskategori
Urologi och njurmedicin
Forskningsämne
epidemiologi; kirurgi, särskilt urologi; onkologi
Identifikatorer
urn:nbn:se:umu:diva-83947 (URN)978-91-7459-763-9 (ISBN)
Disputation
2014-01-24, Hörsal E04, byggnad 6E, Norrlands Universitetssjukhus, Umeå, 09:00 (Engelska)
Opponent
Handledare
Projekt
Me-Can
Forskningsfinansiär
Cancerfonden, 2010/628
Anmärkning

Ytterligare forskningsfinansiärer: World Cancer Research Fund (2007/09) och Wereld Kanker Onderzoek Fonds (R2010/247)

Tillgänglig från: 2013-12-17 Skapad: 2013-12-11 Senast uppdaterad: 2018-06-08Bibliografiskt granskad

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Häggström, ChristelStocks, TanjaLjungberg, BörjeHallmans, GöranJonsson, HåkanStattin, Pär

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