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Brain Characteristics of Individuals Resisting Age-Related Cognitive Decline over Two Decades
Umeå universitet, Medicinska fakulteten, Institutionen för integrativ medicinsk biologi (IMB), Fysiologi. Umeå universitet, Medicinska fakulteten, Umeå centrum för funktionell hjärnavbildning (UFBI).
Umeå universitet, Medicinska fakulteten, Umeå centrum för funktionell hjärnavbildning (UFBI).
Umeå universitet, Samhällsvetenskapliga fakulteten, Handelshögskolan vid Umeå universitet, Statistik.
Umeå universitet, Samhällsvetenskapliga fakulteten, Statistiska institutionen.
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2013 (Engelska)Ingår i: Journal of Neuroscience, ISSN 0270-6474, E-ISSN 1529-2401, Vol. 33, nr 20, s. 8668-8677Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Some elderly appear to resist age-related decline in cognitive functions, but the neural correlates of successful cognitive aging are not well known. Here, older human participants from a longitudinal study were classified as successful or average relative to the mean attrition-corrected cognitive development across 15-20 years in a population-based sample (n = 1561). Fifty-one successful elderly and 51 age-matched average elderly (mean age: 68.8 years) underwent functional magnetic resonance imaging while performing an episodic memory face-name paired-associates task. Successful older participants had higher BOLD signal during encoding than average participants, notably in the bilateral PFC and the left hippocampus (HC). The HC activation of the average, but not the successful, older group was lower than that of a young reference group (n = 45, mean age: 35.3 years). HC activation was correlated with task performance, thus likely contributing to the superior memory performance of successful older participants. The frontal BOLD response pattern might reflect individual differences present from young age. Additional analyses confirmed that both the initial cognitive level and the slope of cognitive change across the longitudinal measurement period contributed to the observed group differences in BOLD signal. Further, the differences between the older groups could not be accounted for by differences in brain structure. The current results suggest that one mechanism behind successful cognitive aging might be preservation of HC function combined with a high frontal responsivity. These findings highlight sources for heterogeneity in cognitive aging and may hold useful information for cognitive intervention studies.

Ort, förlag, år, upplaga, sidor
2013. Vol. 33, nr 20, s. 8668-8677
Nationell ämneskategori
Medicinska och farmaceutiska grundvetenskaper
Identifikatorer
URN: urn:nbn:se:umu:diva-73534DOI: 10.1523/JNEUROSCI.2900-12.2013ISI: 000319112600009PubMedID: 23678111OAI: oai:DiVA.org:umu-73534DiVA, id: diva2:632429
Tillgänglig från: 2013-06-25 Skapad: 2013-06-25 Senast uppdaterad: 2018-06-08Bibliografiskt granskad
Ingår i avhandling
1. Attrition in Studies of Cognitive Aging
Öppna denna publikation i ny flik eller fönster >>Attrition in Studies of Cognitive Aging
2013 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Alternativ titel[sv]
Bortfall i studier av kognitivt åldrande
Abstract [en]

Longitudinal studies of cognition are preferred to cross-sectional stud- ies, since they offer a direct assessment of age-related cognitive change (within-person change). Statistical methods for analyzing age-related change are widely available. There are, however, a number of challenges accompanying such analyzes, including cohort differences, ceiling- and floor effects, and attrition. These difficulties challenge the analyst and puts stringent requirements on the statistical method being used.

The objective of Paper I is to develop a classifying method to study discrepancies in age-related cognitive change. The method needs to take into account the complex issues accompanying studies of cognitive aging, and specifically work out issues related to attrition. In a second step, we aim to identify predictors explaining stability or decline in cognitive performance in relation to demographic, life-style, health-related, and genetic factors.

In the second paper, which is a continuation of Paper I, we investigate brain characteristics, structural and functional, that differ between suc- cessful aging elderly and elderly with an average cognitive performance over 15-20 years.

In Paper III we develop a Bayesian model to estimate the causal effect of living arrangement (living alone versus living with someone) on cog- nitive decline. The model must balance confounding variables between the two living arrangement groups as well as account for non-ignorable attrition. This is achieved by combining propensity score matching with a pattern mixture model for longitudinal data.

In paper IV, the objective is to adapt and implement available impu- tation methods to longitudinal fMRI data, where some subjects are lost to follow-up. We apply these missing data methods to a real dataset, and evaluate these methods in a simulation study.

Ort, förlag, år, upplaga, sidor
Umeå: Umeå universitet, 2013. s. 21
Serie
Statistical studies, ISSN 1100-8989 ; 47
Nyckelord
Attrition, missing data, age-related cognitive change, non- ignorable dropout, monotone missing pattern, mixture models, pattern- mixture models, imputation
Nationell ämneskategori
Övrig annan samhällsvetenskap
Forskningsämne
statistik
Identifikatorer
urn:nbn:se:umu:diva-82514 (URN)978-91-7459-760-8 (ISBN)
Disputation
2013-11-29, Humanisthuset, Hörsal F, Umeå universitet, Umeå, 10:15 (Engelska)
Opponent
Handledare
Tillgänglig från: 2013-11-08 Skapad: 2013-11-04 Senast uppdaterad: 2018-06-08Bibliografiskt granskad

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Pudas, SaraJosefsson, Mariade Luna, XavierNilsson, Lars-GöranNyberg, Lars

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