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Associations between lactase persistence and the metabolic syndrome in a cross-sectional study in the Canary Islands
Vise andre og tillknytning
2010 (engelsk)Inngår i: European Journal of Nutrition, ISSN 1436-6207, E-ISSN 1436-6215, Vol. 49, nr 3, s. 141-146Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

BACKGROUND: The single nucleotide polymorphism (SNP) LCT -13910 C>T, associated with genetically determined phenotypes of lactase persistence (LP) or non-persistence (LNP), was studied in relation to the metabolic syndrome (MS).

AIM OF THE STUDY: The aim was to determine if milk intake and MS are associated. We applied Mendelian randomization (MR). The SNP, LCT -13910 C>T, with the genotypes LP (TT/CT) and LNP (CC), was taken as a proxy for milk consumption.

METHODS: A representative sample of adults belonging to the Canary Islands Nutrition Survey (ENCA) in Spain aged 18-75 years (n = 551) was genotyped for the LCT -13910 C>T polymorphism. We used the International Diabetes Federation (IDF) criteria to define MS.

RESULTS: 60% of the population was LP and 40% LNP. One hundred seven LP subjects (35.0%) and 53 LNP subjects (25.6%) showed MS (chi (2) = 5.04, p = 0.025). LP subjects showed a significantly higher odds ratio (OR) for MS than LNP subjects computed for the whole population: both the crude OR (1.56; 95% CI 1.06-2.31) and adjusted OR for sex, age, daily energy intake, physical activity and educational level (1.57; 95% CI 1.02-2.43). Adjusted OR for women with LP was 1.93; 95% CI 1.06-3.52.

CONCLUSIONS: The T allele of the SNP might constitute a nutrigenetic factor increasing the susceptibility of LP subjects, especially women, to develop MS in the Canary Islands.

sted, utgiver, år, opplag, sider
2010. Vol. 49, nr 3, s. 141-146
HSV kategori
Identifikatorer
URN: urn:nbn:se:umu:diva-79790DOI: 10.1007/s00394-009-0058-2ISI: 000275631500002PubMedID: 19844753OAI: oai:DiVA.org:umu-79790DiVA, id: diva2:644871
Tilgjengelig fra: 2013-09-02 Laget: 2013-09-02 Sist oppdatert: 2018-06-08bibliografisk kontrollert

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