Indentation loading response of a resonance sensor: discriminating prostate cancer and normal tissueShow others and affiliations
2013 (English)In: Journal of Medical Engineering & Technology, ISSN 0309-1902, E-ISSN 1464-522X, Vol. 37, no 7, p. 416-423Article in journal (Refereed) Published
Abstract [en]
Prostate cancer is the most common type of cancer among men worldwide. Mechanical properties of prostate tissue are promising for distinguishing prostate cancer from healthy prostate tissue. The aim was to investigate the indentation loading response of a resonance sensor for discriminating prostate cancer tissue from normal tissue. Indentation measurements were done on prostate tissue specimens ex vivo from 10 patients from radical prostatectomy. The measurement areas were analysed using standard histological methods. The stiffness parameter was linearly dependent on the loading force (average R2 = 0.90) and an increased loading force caused a greater stiffness contrast of prostate cancer vs normal tissue. The accuracy of the stiffness contrast was assessed by the ROC curve with the area under the curve being 0.941 for a loading force of 12.8 mN. The results are promising for the development of a resonance sensor instrument for detecting prostate cancer.
Place, publisher, year, edition, pages
Taylor & Francis, 2013. Vol. 37, no 7, p. 416-423
Keywords [en]
Indentation, loading, prostate cancer, resonance sensor, stiffness
National Category
Medical Engineering Medical Laboratory and Measurements Technologies
Identifiers
URN: urn:nbn:se:umu:diva-79947DOI: 10.3109/03091902.2013.824510Scopus ID: 2-s2.0-84884582200OAI: oai:DiVA.org:umu-79947DiVA, id: diva2:645347
2013-09-042013-09-042023-03-23Bibliographically approved