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Emerging knowledge of regulatory roles of D-amino acids in bacteria
Channing Laboratory, Brigham and Women’s Hospital, Harvard Medical School, and Howard Hughes Medical Institute, Boston, USA.
Channing Laboratory, Brigham and Women’s Hospital, Harvard Medical School, and Howard Hughes Medical Institute, Boston, USA.
Centro de Biología Molecular "Severo Ochoa" Consejo Superior de Investigaciones Científicas, Universidad Autónoma de Madrid, Spain.
Channing Laboratory, Brigham and Women’s Hospital, Harvard Medical School, and Howard Hughes Medical Institute, Boston, USA.
2011 (Engelska)Ingår i: Cellular and Molecular Life Sciences (CMLS), ISSN 1420-682X, E-ISSN 1420-9071, Vol. 68, nr 5, s. 817-831Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

The D-enantiomers of amino acids have been thought to have relatively minor functions in biological processes. While L-amino acids clearly predominate in nature, D-amino acids are sometimes found in proteins that are not synthesized by ribosomes, and D-Ala and D-Glu are routinely found in the peptidoglycan cell wall of bacteria. Here, we review recent findings showing that D-amino acids have previously unappreciated regulatory roles in the bacterial kingdom. Many diverse bacterial phyla synthesize and release D-amino acids, including D-Met and D-Leu, which were not previously known to be made. These noncanonical D-amino acids regulate cell wall remodeling in stationary phase and cause biofilm dispersal in aging bacterial communities. Elucidating the mechanisms by which D-amino acids govern cell wall remodeling and biofilm disassembly will undoubtedly reveal new paradigms for understanding how extracytoplasmic processes are regulated as well as lead to development of novel therapeutics.

Ort, förlag, år, upplaga, sidor
2011. Vol. 68, nr 5, s. 817-831
Nyckelord [en]
D-amino acid, racemase, stationary phase, peptidoglycan, biofilm, regulation
Nationell ämneskategori
Medicinsk bioteknologi (med inriktning mot cellbiologi (inklusive stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci)
Identifikatorer
URN: urn:nbn:se:umu:diva-81861DOI: 10.1007/s00018-010-0571-8ISI: 000287243400006PubMedID: 21161322OAI: oai:DiVA.org:umu-81861DiVA, id: diva2:658605
Tillgänglig från: 2013-10-22 Skapad: 2013-10-22 Senast uppdaterad: 2018-06-08Bibliografiskt granskad

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