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CSF dynamic analysis of a predictive pulsatility-based infusion test for normal pressure hydrocephalus
Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper, Radiofysik.
Umeå universitet, Medicinska fakulteten, Institutionen för farmakologi och klinisk neurovetenskap, Klinisk neurovetenskap.ORCID-id: 0000-0001-6451-1940
Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper, Radiofysik.
2014 (engelsk)Inngår i: Medical and Biological Engineering and Computing, ISSN 0140-0118, E-ISSN 1741-0444, Vol. 52, nr 1, s. 75-85Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Disturbed cerebrospinal fluid (CSF) dynamics are part of the pathophysiology of normal pressure hydrocephalus (NPH) and can be modified and treated with shunt surgery. This study investigated the contribution of established CSF dynamic parameters to AMPmean, a prognostic variable defined as mean amplitude of cardiac-related intracranial pressure pulsations during 10 min of lumbar constant infusion, with the aim of clarifying the physiological interpretation of the variable. AMPmean and CSF dynamic parameters were determined from infusion tests performed on 18 patients with suspected NPH. Using a mathematical model of CSF dynamics, an expression for AMPmean was derived and the influence of the different parameters was assessed. There was high correlation between modelled and measured AMPmean (r = 0.98, p < 0.01). Outflow resistance and three parameters relating to compliance were identified from the model. Correlation analysis of patient data confirmed the effect of the parameters on AMPmean (Spearman's ρ = 0.58-0.88, p < 0.05). Simulated variations of ±1 standard deviation (SD) of the parameters resulted in AMPmean changes of 0.6-2.9 SD, with the elastance coefficient showing the strongest influence. Parameters relating to compliance showed the largest contribution to AMPmean, which supports the importance of the compliance aspect of CSF dynamics for the understanding of the pathophysiology of NPH.

sted, utgiver, år, opplag, sider
2014. Vol. 52, nr 1, s. 75-85
Emneord [en]
Cerebrospinal fluid dynamics, Prognostic tests, Intracranial pressure, Normal pressure hydrocephalus
HSV kategori
Identifikatorer
URN: urn:nbn:se:umu:diva-82750DOI: 10.1007/s11517-013-1110-1ISI: 000329663200008PubMedID: 24151060OAI: oai:DiVA.org:umu-82750DiVA, id: diva2:662917
Tilgjengelig fra: 2013-11-08 Laget: 2013-11-08 Sist oppdatert: 2018-06-08bibliografisk kontrollert
Inngår i avhandling
1. Analysis of ICP pulsatility and CSF dynamics: the pulsatility curve and effects of postural changes, with implications for idiopathic normal pressure hydrocephalus
Åpne denne publikasjonen i ny fane eller vindu >>Analysis of ICP pulsatility and CSF dynamics: the pulsatility curve and effects of postural changes, with implications for idiopathic normal pressure hydrocephalus
2013 (engelsk)Doktoravhandling, med artikler (Annet vitenskapelig)
Alternativ tittel[sv]
Analys av ICP-pulsationer och CSF-dynamik : pulsationskurvan och effekter av ändrad kroppsposition, med implikationer för idiopatisk normaltryckshydrocefalus
Abstract [en]

The volume defined by the rigid cranium is shared by the brain, blood and cerebrospinal fluid (CSF). With every heartbeat the arterial blood volume briefly increases and venous blood and CSF are forced out of the cranium, leading to pulsatility in CSF flow and intracranial pressure (ICP). Altered CSF pulsatility has been linked to idiopathic normal pressure hydrocephalus (INPH), which involves enlarged cerebral ventricles and symptoms of gait/balance disturbance, cognitive decline and urinary incontinence that may be improved by implantation of a shunt. The overall aim of this thesis was to investigate the fluid dynamics of the CSF system, with a focus on pulsatility, and how they relate to INPH pathophysiology and treatment.

Mathematical modelling was applied to data from infusion tests, where the ICP response to CSF volume manipulation is measured, to analyse the relationship between mean ICP and ICP pulse amplitude (AMP) before and after shunt surgery in INPH (paper I-II). The observed relationship, designated the pulsatility curve, was found to be constant at low ICP and linear at high ICP, corresponding to a shift from constant to ICP dependent compliance (paper I). Shunt surgery did not affect the pulsatility curve, but shifted baseline ICP and AMP along the curve towards lower values. Patients who improved in gait after surgery had significantly larger AMP reduction than those who did not, while ICP reduction was similar, suggesting that improving patients had baseline ICP in the linear zone of the curve before surgery. Use of this phenomenon for outcome prediction was promising (paper II). The fluid dynamics of an empirically derived pulsatility-based predictive infusion test for INPH was also investigated, with results showing strong influence from compliance (paper III).

Clinical ICP data at different body postures was used to evaluate three models describing postural effects on ICP. ICP decreased in upright positions, whereas AMP increased. The model describing the postural effects based on hydrostatic changes in the venous system, including effects of collapse of the jugular veins in the upright position, accurately predicted the measured ICP (paper IV).

Cerebral blood flow and CSF flow in the aqueduct and at the cervical level was measured with phase contrast magnetic resonance imaging, and compared between healthy elderly and INPH (paper V). Cerebral blood flow and CSF flow at the cervical level were similar in INPH patients and healthy elderly, whereas aqueductal CSF flow differed significantly. The pulsatility in the aqueduct flow was increased, and there was more variation in the net flow in INPH, but the mean net flow was normal, i.e. directed from the ventricles to the subarachnoid space (paper V).

In conclusion, this thesis introduced the concept of pulsatility curve analysis, and provided evidence that pulsatility and compliance are important aspects for successful shunt treatment and outcome prediction in INPH. It was further confirmed that enhanced pulsatility of aqueduct CSF flow was the most distinct effect of INPH pathophysiology on cerebral blood flow and CSF flow. A new model describing postural and hydrostatic effects on ICP was presented, and the feasibility and potential importance of measuring ICP in the upright position in INPH was demonstrated. 

sted, utgiver, år, opplag, sider
Umeå: Umeå Universitet, 2013. s. 79
Serie
Umeå University medical dissertations, ISSN 0346-6612 ; 1613
Emneord
Cerebrospinal fluid, CSF dynamics, Intracranial pressure, Pulse pressure, Normal pressure hydrocephalus, Posture, Predictive tests, Mathematical modelling, Magnetic resonance imaging, Infusion tests
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-82784 (URN)978-91-7459-762-2 (ISBN)
Disputas
2013-12-06, Hörsal E 04, Unod R1, Norrlands Universitetssjukhus, Umeå, 13:00 (engelsk)
Opponent
Veileder
Forskningsfinansiär
Swedish Research Council, 221-2011-5216Swedish Research Council, VR3011-2006-7551Vinnova, VR3011-2006-7551Swedish Foundation for Strategic Research , VR3011-2006-7551
Merknad

Forskningsfinansiär: 

European Union, ERDF: Objective 2, Northern Sweden (grant no. 158715-CMTF). 

Tilgjengelig fra: 2013-11-15 Laget: 2013-11-11 Sist oppdatert: 2018-06-08bibliografisk kontrollert

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