Umeå University's logo

umu.sePublikasjoner
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Vitamin A metabolism, action, and role in skeletal homeostasis
Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
2013 (engelsk)Inngår i: Endocrine reviews, ISSN 0163-769X, E-ISSN 1945-7189, Vol. 34, nr 6, s. 766-797Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Vitamin A (retinol) is ingested as either retinyl esters or carotenoids and metabolized to active compounds, such as 11-cis-retinal, which is important for vision, and all-trans-retinoic acid (ATRA), which is the primary mediator of biological actions of vitamin A. ATRA binds to retinoic acid receptors (RARs), which heterodimerize with retinoid X receptors (RXRs). RAR-RXR heterodimers function as transcription factors, binding RAR responsive elements in promoters of different genes. Numerous cellular functions, including bone cell functions, are mediated by vitamin A; however, it has long been recognized that increased levels of vitamin A can have deleterious effects on bone resulting in increased skeletal fragility. Bone mass is dependent on the balance between bone resorption and bone formation. A decrease in bone mass may be caused by either an excess of resorption or decreased bone formation. Early studies indicated that the primary skeletal effect of vitamin A was to increase bone resorption, but later studies have shown that vitamin A can not only stimulate the formation of bone resorbing osteoclasts, but inhibit their formation as well. Effects of vitamin A on bone formation have not been studied in as great a detail and are not as well characterized as effects on bone resorption. Several epidemiological studies have shown an association between vitamin A, decreased bone mass, and osteoporotic fractures, but the data are not conclusive, for other studies have found no associations, and some studies have suggested that vitamin A primarily promotes skeletal health. In this presentation, we have summarized how vitamin A is absorbed, metabolized, and functions intracellularly. Vitamin A deficiency and excess are introduced, and detailed descriptions of clinical and pre-clinical studies of the effects of vitamin A on the skeleton are presented.

sted, utgiver, år, opplag, sider
The Endocrine Society , 2013. Vol. 34, nr 6, s. 766-797
HSV kategori
Identifikatorer
URN: urn:nbn:se:umu:diva-82917DOI: 10.1210/er.2012-1071ISI: 000328082900003PubMedID: 23720297Scopus ID: 2-s2.0-84890840898OAI: oai:DiVA.org:umu-82917DiVA, id: diva2:663918
Tilgjengelig fra: 2013-11-13 Laget: 2013-11-13 Sist oppdatert: 2023-03-23bibliografisk kontrollert

Open Access i DiVA

Fulltekst mangler i DiVA

Andre lenker

Forlagets fulltekstPubMedScopus

Person

Lerner, Ulf H.

Søk i DiVA

Av forfatter/redaktør
Lerner, Ulf H.
Av organisasjonen
I samme tidsskrift
Endocrine reviews

Søk utenfor DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric

doi
pubmed
urn-nbn
Totalt: 199 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf