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Aberrant VHGene Utilization in Patients with Established Insulin-Dependent Diabetes Mellitus
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Medicin.
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Medicin.
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1997 (Engelska)Ingår i: Journal of Autoimmunity, ISSN 0896-8411, E-ISSN 1095-9157, Vol. 10, nr 2, s. 157-163Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

We have compared the B-lymphocyte repertoire in seven IDDM patients with 12 healthy controls by examining the variable heavy (VH) gene expression. The VHgene representation in the pool of pokeweed mitogen (PWM) stimulated, immunocompetent B cells and in the pool of naturally activated plasma cells (actual repertoire) was analysed by RNA-RNA in situ hybridization. Differences between IDDM patients and normal controls in the relative expression of several VHgene families were observed. In IDDM patients, the VH3 was significantly underrepresented in the PWM stimulated repertoire. In the actual B cell repertoire the VH5 clones were underrepresented among diabetic patients. Moreover, the altered distribution of VHgene usage between the PWM stimulated repertoire and the actual repertoire observed in normal controls was found to be less pronounced in the IDDM patients. This observation suggests a defect in the V-gene directed cellular selection occurring between resting, immunocompetent B cells and naturally activated plasma cells. The possible implication of the observed aberrations in the B cell selection process for the pathogenesis of autoimmunity is discussed.

Ort, förlag, år, upplaga, sidor
1997. Vol. 10, nr 2, s. 157-163
Nyckelord [en]
B cell repertoire, IDDM, VHgene family
Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
URN: urn:nbn:se:umu:diva-84187ISI: A1997XA35100006PubMedID: 9185877OAI: oai:DiVA.org:umu-84187DiVA, id: diva2:679919
Tillgänglig från: 2013-12-17 Skapad: 2013-12-17 Senast uppdaterad: 2018-06-08Bibliografiskt granskad

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Hillörn, ValterSöderström, IngegerdHägg, ErikHolmberg, Dan

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