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A cis-encoded sRNA controls the expression of fabH2 in Yersinia
Chinese Academy of Sciences, Wuhan, China.
Chinese Academy of Sciences, Wuhan, China.
Chinese Academy of Sciences, Wuhan, China.
Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet). Umeå universitet, Medicinska fakulteten, Umeå Centre for Microbial Research (UCMR). (Matthew Francis)
Vise andre og tillknytning
2014 (engelsk)Inngår i: FEBS Letters, ISSN 0014-5793, E-ISSN 1873-3468, Vol. 588, nr 10, s. 1961-1966Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

YsrH is a novel cis-encoded sRNA located on the opposite strand to fabH2, which is essential for fatty acid biosynthesis in bacteria. In this study, YsrH-mediated regulation of fabH2 expression was investigated in Yersinia pseudotuberculosis. Constitutive and inducible over-expression of YsrH decreased the mRNA level of fabH2, while expression of downstream fabD and fabG remained unaffected. Polynucleotide phosphorylase (PNPase) also played an important role in this regulation process by mediating YsrH decay in the exponential phase. Thus, our data defines a cis-encoded sRNA that regulates fatty acid synthesis via a regulatory mechanism also involving PNPase.

sted, utgiver, år, opplag, sider
2014. Vol. 588, nr 10, s. 1961-1966
Emneord [en]
3-oxoacyl-ACP synthase (fabH2); Yersinia sRNA regulator of fabH2 (YsrH); cis-Encoded sRNA; PNPase; Yersinia
HSV kategori
Forskningsprogram
mikrobiologi; molekylärbiologi
Identifikatorer
URN: urn:nbn:se:umu:diva-88605DOI: 10.1016/j.febslet.2014.04.005ISI: 000336033700016PubMedID: 24735725OAI: oai:DiVA.org:umu-88605DiVA, id: diva2:716500
Tilgjengelig fra: 2014-05-09 Laget: 2014-05-09 Sist oppdatert: 2018-06-07bibliografisk kontrollert

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