umu.sePublikationer
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
The need for high-quality whole-genome sequence databases in microbial forensics
Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen.
Visa övriga samt affilieringar
2013 (Engelska)Ingår i: Biosecurity and bioterrorism, ISSN 1538-7135, E-ISSN 1557-850X, Vol. 11, nr Supplement 1, s. S78-S86Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Microbial forensics is an important part of a strengthened capability to respond to biocrime and bioterrorism incidents to aid in the complex task of distinguishing between natural outbreaks and deliberate acts. The goal of a microbial forensic investigation is to identify and criminally prosecute those responsible for a biological attack, and it involves a detailed analysis of the weapon-that is, the pathogen. The recent development of next-generation sequencing (NGS) technologies has greatly increased the resolution that can be achieved in microbial forensic analyses. It is now possible to identify, quickly and in an unbiased manner, previously undetectable genome differences between closely related isolates. This development is particularly relevant for the most deadly bacterial diseases that are caused by bacterial lineages with extremely low levels of genetic diversity. Whole-genome analysis of pathogens is envisaged to be increasingly essential for this purpose. In a microbial forensic context, whole-genome sequence analysis is the ultimate method for strain comparisons as it is informative during identification, characterization, and attribution-all 3 major stages of the investigation-and at all levels of microbial strain identity resolution (ie, it resolves the full spectrum from family to isolate). Given these capabilities, one bottleneck in microbial forensics investigations is the availability of high-quality reference databases of bacterial whole-genome sequences. To be of high quality, databases need to be curated and accurate in terms of sequences, metadata, and genetic diversity coverage. The development of whole-genome sequence databases will be instrumental in successfully tracing pathogens in the future.

Ort, förlag, år, upplaga, sidor
2013. Vol. 11, nr Supplement 1, s. S78-S86
Nationell ämneskategori
Rättsmedicin
Identifikatorer
URN: urn:nbn:se:umu:diva-90483DOI: 10.1089/bsp.2013.0007ISI: 000336524100010OAI: oai:DiVA.org:umu-90483DiVA, id: diva2:732677
Tillgänglig från: 2014-07-04 Skapad: 2014-06-23 Senast uppdaterad: 2018-03-15Bibliografiskt granskad

Open Access i DiVA

fulltext(205 kB)208 nedladdningar
Filinformation
Filnamn FULLTEXT01.pdfFilstorlek 205 kBChecksumma SHA-512
3ab34bc51b9ed1befc2d3cc883970d1a48a72f53837d0eada3652f0ae1fd3cf648c89a4f3e586c2f82fa30fbb8d6bd5f1926d166de9263332bc036913217347b
Typ fulltextMimetyp application/pdf

Övriga länkar

Förlagets fulltext
Av organisationen
Kemiska institutionen
I samma tidskrift
Biosecurity and bioterrorism
Rättsmedicin

Sök vidare utanför DiVA

GoogleGoogle Scholar
Totalt: 208 nedladdningar
Antalet nedladdningar är summan av nedladdningar för alla fulltexter. Det kan inkludera t.ex tidigare versioner som nu inte längre är tillgängliga.

doi
urn-nbn

Altmetricpoäng

doi
urn-nbn
Totalt: 77 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf