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Human transgenerational responses to early-life experience: potential impact on development, health and biomedical research
Umeå universitet, Medicinska fakulteten, Institutionen för samhällsmedicin och rehabilitering. (Department of Bioscience and Nutrition, Karolinska Institute, Stockholm, Sweden)
2014 (Engelska)Ingår i: Journal of Medical Genetics, ISSN 0022-2593, E-ISSN 1468-6244, Journal of Medical Genetics, ISSN 0022-2593, Vol. 51, nr 9, s. 563-572Artikel, forskningsöversikt (Refereegranskat) Published
Abstract [en]

Mammalian experiments provide clear evidence of male line transgenerational effects on health and development from paternal or ancestral early-life exposures such as diet or stress. The few human observational studies to date suggest (male line) transgenerational effects exist that cannot easily be attributed to cultural and/or genetic inheritance. Here we summarise relevant studies, drawing attention to exposure sensitive periods in early life and sex differences in transmission and offspring outcomes. Thus, variation, or changes, in the parental/ancestral environment may influence phenotypic variation for better or worse in the next generation(s), and so contribute to common, non-communicable disease risk including sex differences. We argue that life-course epidemiology should be reframed to include exposures from previous generations, keeping an open mind as to the mechanisms that transmit this information to offspring. Finally, we discuss animal experiments, including the role of epigenetic inheritance and non-coding RNAs, in terms of what lessons can be learnt for designing and interpreting human studies. This review was developed initially as a position paper by the multidisciplinary Network in Epigenetic Epidemiology to encourage transgenerational research in human cohorts.

Ort, förlag, år, upplaga, sidor
BMJ Books, 2014. Vol. 51, nr 9, s. 563-572
Nationell ämneskategori
Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi
Identifikatorer
URN: urn:nbn:se:umu:diva-92902DOI: 10.1136/jmedgenet-2014-102577ISI: 000340242400001OAI: oai:DiVA.org:umu-92902DiVA, id: diva2:748200
Tillgänglig från: 2014-09-18 Skapad: 2014-09-09 Senast uppdaterad: 2018-06-07Bibliografiskt granskad

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Bygren, Lars Olov

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Journal of Medical Genetics
Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi

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