umu.sePublikasjoner
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Combined impact of healthy lifestyle factors on colorectal cancer: a large European cohort study
Vise andre og tillknytning
2014 (engelsk)Inngår i: BMC Medicine, ISSN 1741-7015, E-ISSN 1741-7015, Vol. 12, nr 1, s. 168-Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

BACKGROUND: Excess body weight, physical activity, smoking, alcohol consumption and certain dietary factors are individually related to colorectal cancer (CRC) risk; however, little is known about their joint effects. The aim of this study was to develop a healthy lifestyle index (HLI) composed of five potentially modifiable lifestyle factors - healthy weight, physical activity, non-smoking, limited alcohol consumption and a healthy diet, and to explore the association of this index with CRC incidence using data collected within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. METHODS: In the EPIC cohort, a total of 347,237 men and women, 25- to 70-years old, provided dietary and lifestyle information at study baseline (1992 to 2000). Over a median follow-up time of 12 years, 3,759 incident CRC cases were identified. The association between a HLI and CRC risk was evaluated using Cox proportional hazards regression models and population attributable risks (PARs) have been calculated. RESULTS: After accounting for study centre, age, sex and education, compared with 0 or 1 healthy lifestyle factors, the hazard ratio (HR) for CRC was 0.87 (95% confidence interval (CI): 0.44 to 0.77) for two factors, 0.79 (95% CI: 0.70 to 0.89) for three factors, 0.66 (95% CI: 0.58 to 0.75) for four factors and 0.63 (95% CI: 0.54 to 0.74) for five factors; P-trend <0.0001. The associations were present for both colon and rectal cancers, HRs, 0.61 (95% CI: 0.50 to 0.74; P for trend <0.0001) for colon cancer and 0.68 (95% CI: 0.53 to 0.88; P-trend <0.0001) for rectal cancer, respectively (P-difference by cancer sub-site = 0.10). Overall, 16% of the new CRC cases (22% in men and 11% in women) were attributable to not adhering to a combination of all five healthy lifestyle behaviours included in the index. CONCLUSIONS: Combined lifestyle factors are associated with a lower incidence of CRC in European populations characterized by western lifestyles. Prevention strategies considering complex targeting of multiple lifestyle factors may provide practical means for improved CRC prevention.

sted, utgiver, år, opplag, sider
BioMed Central, 2014. Vol. 12, nr 1, s. 168-
Emneord [en]
acrylamide, dietary questionnaires, haemoglobin adducts, biomarkers, smoking, measurement errors, lifestyle factors, combined impact, population attributable risks, colorectal cancer, European Prospective Investigation into Cancer and Nutrition (EPIC)
HSV kategori
Identifikatorer
URN: urn:nbn:se:umu:diva-95215DOI: 10.1186/s12916-014-0168-4ISI: 000344889900001PubMedID: 25319089OAI: oai:DiVA.org:umu-95215DiVA, id: diva2:757972
Tilgjengelig fra: 2014-10-24 Laget: 2014-10-24 Sist oppdatert: 2017-12-05bibliografisk kontrollert

Open Access i DiVA

fulltext(439 kB)146 nedlastinger
Filinformasjon
Fil FULLTEXT02.pdfFilstørrelse 439 kBChecksum SHA-512
51b5a5da960cd6b5831b7905887c77370ace8dcef11d296741d5f9e7d9f52f5c86c70c4a32bb15501da7352b06b9f1e2c8fd8f554f7b0ffc705c95978efabb73
Type fulltextMimetype application/pdf

Andre lenker

Forlagets fulltekstPubMed

Søk i DiVA

Av forfatter/redaktør
Ljuslinder, IngridJohansson, Ingegerd
Av organisasjonen
I samme tidsskrift
BMC Medicine

Søk utenfor DiVA

GoogleGoogle Scholar
Totalt: 147 nedlastinger
Antall nedlastinger er summen av alle nedlastinger av alle fulltekster. Det kan for eksempel være tidligere versjoner som er ikke lenger tilgjengelige

doi
pubmed
urn-nbn

Altmetric

doi
pubmed
urn-nbn
Totalt: 317 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf