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Pectosomes and chitosomes as delivery systems for metronidazole: the one-pot preparation method
Umeå universitet, Medicinska fakulteten, Institutionen för farmakologi och klinisk neurovetenskap, Klinisk farmakologi.
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2013 (Engelska)Ingår i: Pharmaceutics, ISSN 1999-4923, E-ISSN 1999-4923, Vol. 5, nr 3, s. 445-456Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Mucoadhesive liposomes offer a potential for improved residence time of liposomal systems targeting contact with mucosal tissues, such as in buccal, oral, colon, and vaginal drug delivery. Most of the currently available methods rely on the coating of preformed liposomes by various mucoadhesive polymers. The aim of this study was to develop novel mucoadhesive system by the one-pot preparation method. The pectin- and chitosan-containing liposomes, namely pectosomes and chitosomes, were prepared by the modified solvent injection method. In order to optimize this novel delivery system, we used pectins and chitosans of both high and low degree of esterification/deacetylation (DE/DD), respectively. Sonication was applied to reduce the original vesicle size. All vesicles were characterized for their size, zeta potential, metronidazole entrapment, and stability. Both pectosomes and chitosomes were found to entrap more metronidazole than conventional plain liposomes. Preliminary data indicate that the polymer is present on the liposomal surface, embedded within inner liposomal bilayers, and entrapped inside the aqueous compartment. The next step in the evaluation of this system is the testing of its mucoadhesiveness.

Ort, förlag, år, upplaga, sidor
M D P I AG , 2013. Vol. 5, nr 3, s. 445-456
Nyckelord [en]
liposomes, pectosomes, chitosomes, metronidazole, mucoadhesion, polymer-coating, vaginal therapy
Nationell ämneskategori
Farmakologi och toxikologi
Identifikatorer
URN: urn:nbn:se:umu:diva-95334DOI: 10.3390/pharmaceutics5030445PubMedID: 24300517OAI: oai:DiVA.org:umu-95334DiVA, id: diva2:758710
Tillgänglig från: 2014-10-28 Skapad: 2014-10-28 Senast uppdaterad: 2018-06-07Bibliografiskt granskad

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Mattsson, Sofia

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