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Primary spinal intradural mesenchymal chondrosarcoma with detection of fusion gene HEY1-NCOA2: a paediatric case report and review of the literature
Vise andre og tillknytning
2014 (engelsk)Inngår i: Oncology Letters, ISSN 1792-1074, E-ISSN 1792-1082, Vol. 8, nr 4, s. 1608-1612Artikkel, forskningsoversikt (Fagfellevurdert) Published
Abstract [en]

Mesenchymal chondrosarcoma is an extremely rare malignant tumour that most commonly originates in the bone, but is also present in extraskeletal sites. The tumour is morphologically characterized by a biphasic pattern of small round cells and islands of cartilage. Spinal mesenchymal chondrosarcomas are even rarer and, therefore, few investigations exist regarding the biological behaviour of the tumours. In the present study, we report a case of a 10-year-old female presenting with 9 months of back pain and radiographic findings of an intradural lesion measuring 1.5 cm at the level of Th4. The tumour was completely excised and subjected to pathological analyses. Following detection of the HEY1-NCOA2 fusion gene, the tumour was morphologically and immunohistochemically defined as an intradural mesenchymal chondrosarcoma attached to the dura mater. In this study, we validate the recent identification of the fusion gene HEY1-NCOA2 in paediatric extraskeletal mesenchymal chondrosarcomas: The relevant literature is reviewed and further discussed in relation to our findings.

sted, utgiver, år, opplag, sider
2014. Vol. 8, nr 4, s. 1608-1612
Emneord [en]
chondrosarcoma, bone tumour, intradural, HEY1-NCOA2, fusion gene, sarcoma
HSV kategori
Identifikatorer
URN: urn:nbn:se:umu:diva-104157DOI: 10.3892/ol.2014.2364ISI: 000342725400038OAI: oai:DiVA.org:umu-104157DiVA, id: diva2:822996
Tilgjengelig fra: 2015-06-17 Laget: 2015-06-08 Sist oppdatert: 2018-06-07bibliografisk kontrollert

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