umu.sePublikationer
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Effects of Combined Milrinone and Levosimendan Treatment on Systolic and Diastolic Function During Postischemic Myocardial Dysfunction in a Porcine Model
Örebro University, Örebro, Sweden .
Umeå universitet, Medicinska fakulteten, Institutionen för kirurgisk och perioperativ vetenskap, Anestesiologi och intensivvård.
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Kardiologi.
Umeå universitet, Medicinska fakulteten, Institutionen för kirurgisk och perioperativ vetenskap, Anestesiologi och intensivvård.ORCID-id: 0000-0002-5325-2688
Visa övriga samt affilieringar
2016 (Engelska)Ingår i: Journal of Cardiovascular Pharmacology and Therapeutics, ISSN 1074-2484, E-ISSN 1940-4034, Vol. 21, nr 5, s. 495-503Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

It is not known whether there are positive or negative interactions on ventricular function when a calcium-sensitizing inotrope is added to a phosphodiesterase inhibitor in the clinical setting of acute left ventricular (LV) dysfunction. We hypothesized that when levosimendan is added to milrinone treatment, there will be synergetic inotropic and lusitropic effects. This was tested in an anesthetized porcine postischemic global LV injury model, where ventricular pressures and volumes (conductance volumetry) were measured. A global ischemic injury was induced by repetitive left main stem coronary artery occlusions. Load-independent indices of LV function were assessed before and after ventricular injury, after milrinone treatment, and finally after addition of levosimendan to the milrinone treatment. Nonparametric, within-group comparisons were made. The protocol was completed in 12 pigs, 7 of which received the inotrope treatment and 5 of which served as controls. Milrinone led to positive lusitropic effects seen by improvement in tau after myocardial stunning. The addition of levosimendan to milrinone further increased lusitropic state. The latter effect could however not be attributed solely to levosimendan, since lusitropic state also improved spontaneously in time-matched controls at the same rate during the corresponding period. When levosimendan was added to milrinone infusion, there was no increase in systolic function (preload recruitable stroke work) compared to milrinone treatment alone. We conclude that in this model of postischemic LV dysfunction, there appears to be no clear improvement in systolic or diastolic function after addition of levosimendan to established milrinone treatment but also no negative effects of levosimendan in this context.

Ort, förlag, år, upplaga, sidor
Sage Publications, 2016. Vol. 21, nr 5, s. 495-503
Nyckelord [en]
cardiac pharmacology, cardioactive agents, experimental and clinical heart failure, ischemia-reperfusion injury
Nationell ämneskategori
Anestesi och intensivvård Kardiologi
Identifikatorer
URN: urn:nbn:se:umu:diva-116180DOI: 10.1177/1074248416628675ISI: 000382567800008PubMedID: 26837238ISBN: 1940-4034 (Electronic) 1074-2484 (Linking) (tryckt)OAI: oai:DiVA.org:umu-116180DiVA, id: diva2:901781
Tillgänglig från: 2016-02-09 Skapad: 2016-02-09 Senast uppdaterad: 2019-05-22Bibliografiskt granskad

Open Access i DiVA

Fulltext saknas i DiVA

Övriga länkar

Förlagets fulltextPubMed

Personposter BETA

Häggmark, SörenSvenmarker, StaffanJohansson, GöranHaney, Michael

Sök vidare i DiVA

Av författaren/redaktören
Häggmark, SörenSvenmarker, StaffanJohansson, GöranHaney, Michael
Av organisationen
Anestesiologi och intensivvårdKardiologi
I samma tidskrift
Journal of Cardiovascular Pharmacology and Therapeutics
Anestesi och intensivvårdKardiologi

Sök vidare utanför DiVA

GoogleGoogle Scholar

doi
pubmed
isbn
urn-nbn

Altmetricpoäng

doi
pubmed
isbn
urn-nbn
Totalt: 386 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf