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Effects of bovine alpha-lactalbumin and casein glycomacropeptide-enriched infant formulae on faecal microbiota in healthy term infants
Vise andre og tillknytning
2006 (engelsk)Inngår i: Journal of Pediatric Gastroenterology and Nutrition - JPGN, ISSN 0277-2116, E-ISSN 1536-4801, Vol. 43, nr 5, s. 673-679Artikkel i tidsskrift (Fagfellevurdert) Published
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Abstract [en]

Objective: Certain milk factors may promote the growth of a host-friendly gastrointestinal microbiota, for example, one that is predominated by bifidobacteria, a perceived healthpromoting genus. This may explain why breast-fed infants experience fewer intestinal infections than their formula-fed counterparts who are believed to have a more diverse microbiota, which is similar to that of adults. The effects of formulas supplemented with 2 such ingredients from bovine milk, a-lactalbumin (alpha-lac) and casein glycomacropeptide (GMP), on gut flora were investigated in this study.

Patients and Methods: Six-week-old (4-8 wk), healthy term infants were randomised to a standard infant formula or 1 of 2 test formulae enriched in alpha-Jac with higher or lower GMP until 6 months. Faecal bacteriology was determined by the culture-independent procedure fluorescence in situ hybridisation.

Results: There was a large fluctuation of bacterial counts within groups with no statistically significant differences between groups. Although all groups showed a. predominance of bifidobacteria, breast-fed infants had a small temporary increase in counts. Other bacterial levels varied in formula-fed groups, which overall showed an adult-like faecal microflora.

Conclusions: It can be speculated that a prebiotic effect for alpha-lac and GMP is achieved only with low starting populations of beneficial microbiota (eg, infants not initially breast-fed).

sted, utgiver, år, opplag, sider
Philadelphia: Lippincott Williams & Wilkins, 2006. Vol. 43, nr 5, s. 673-679
Emneord [en]
infant nutrition, casein glycomacropeptide, alpha-lactalbumin, fluorescence in situ hybridization, human trials
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Identifikatorer
URN: urn:nbn:se:umu:diva-119374DOI: 10.1097/01.mpg.0000232019.79025.8fISI: 000241906800022PubMedID: 17130747OAI: oai:DiVA.org:umu-119374DiVA, id: diva2:928709
Tilgjengelig fra: 2016-05-16 Laget: 2016-04-18 Sist oppdatert: 2018-06-07bibliografisk kontrollert

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Bruck, Wolfram MTuohy, Kieran MHernell, Olle

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