Umeå universitets logga

umu.sePublikationer
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
New molecules in the tumor necrosis factor ligand and receptor superfamilies with importance for physiological and pathological bone resorption
Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Oral cellbiologi.
2004 (Engelska)Ingår i: Critical Reviews in Oral Biology and Medicine, ISSN 1045-4411, E-ISSN 1544-1113, Vol. 15, nr 2, s. 64-81Artikel, forskningsöversikt (Refereegranskat) Published
Resurstyp
Text
Abstract [en]

Osteoclasts are tissue-specific polykaryon bone-resorbing cells derived from the monocyte/macrophage hematopoietic lineage with specialized functions required for the adhesion of the cells to bone and the subsequent polarization of the cell membrane, secretion of acid to dissolve mineral crystals, and release of proteolytic enzymes to degrade the extracellular matrix proteins. Most pathological conditions in the skeleton lead to loss of bone due to excess osteoclastic bone resorption, including periodontal disease, rheumatoid arthritis, and osteoporosis. In rare cases, most of them genetic, patients with osteopetrosis exhibit sclerotic bone due either to a lack of osteoclasts or to non-functional osteoclasts. Mainly because of phenotypic findings in genetically manipulated mice or due to spontaneous mutations in humans, mice, and rats, several genes have been discovered as being crucial for osteoclast formation and activation. Recent breakthroughs in our understanding of osteoclast biology have revealed the critical roles in osteoclast differentiation played by RANKL, RANK, and OPG, three novel members of the tumor necrosis factor ligand and receptor superfamilies. The further study of these molecules and downstream signaling events are likely to provide a molecular basis for the development of new drugs for the treatment of diseases with excess or deficient osteoclastic bone resorption.

Ort, förlag, år, upplaga, sidor
Alexandria: International association for dental research (IADR) , 2004. Vol. 15, nr 2, s. 64-81
Nyckelord [en]
RANKL, OPG, osteoclasts, periodontal disease, osteopetrosis, osteoporosis
Nationell ämneskategori
Odontologi Kirurgi
Identifikatorer
URN: urn:nbn:se:umu:diva-122174DOI: 10.1177/154411130401500202ISI: 000226792600001Scopus ID: 2-s2.0-11144336228OAI: oai:DiVA.org:umu-122174DiVA, id: diva2:938992
Tillgänglig från: 2016-06-17 Skapad: 2016-06-15 Senast uppdaterad: 2023-03-24Bibliografiskt granskad

Open Access i DiVA

Fulltext saknas i DiVA

Övriga länkar

Förlagets fulltextScopus

Person

Lerner, Ulf H

Sök vidare i DiVA

Av författaren/redaktören
Lerner, Ulf H
Av organisationen
Oral cellbiologi
I samma tidskrift
Critical Reviews in Oral Biology and Medicine
OdontologiKirurgi

Sök vidare utanför DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetricpoäng

doi
urn-nbn
Totalt: 213 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf