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Simultaneously elevated exhaled nitric oxide and serum-ECP relate to recent asthma events in asthmatics in a cross sectional population based study
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2016 (Engelska)Ingår i: Clinical and Experimental Allergy, ISSN 0954-7894, E-ISSN 1365-2222, Vol. 46, nr 12, s. 1540-1548Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

BACKGROUND: We have reported that increased fraction of exhaled nitric oxide (FeNO), a measure of TH2 -driven airway inflammation, and blood eosinophil count, a marker of systemic eosinophil inflammation, correlated with asthma attacks in a population-based study.

OBJECTIVE: To investigate the relation between simultaneously elevated FeNO and serum eosinophil cationic protein (S-ECP) levels and asthma events among asthmatics.

METHODS: Measurements of FeNO (elevated ≥ 25 ppb) and S-ECP (elevated ≥ 20 ng/mL) were done in 339 adult asthmatics. Asthma events (attacks and symptoms) were self-reported.

RESULTS: Simultaneously normal S-ECP and FeNO levels were found in 48% of the subjects. Subjects with simultaneously elevated S-ECP and FeNO (13% of the population) had a higher prevalence of asthma attacks in the preceding 3 months than subjects with normal S-ECP and FeNO (51% vs. 25%, p = 0.001). This was not found for subjects with singly elevated S-ECP (p = 0.14) or FeNO (p = 0.34) levels. Elevated S-ECP and FeNO levels was independently associated to asthma attacks in the preceding 3 months after adjusting for potential confounders (OR (95% CI) 4.2 (2.0-8.8).

CONCLUSIONS: Simultaneous elevated FeNO and S-ECP related to a higher likelihood of asthma attacks in the preceding 3 months. This indicates that there is a value in measuring both FeNO and systemic eosinophilic inflammation in patients with asthma in order to identify individuals at high risk of exacerbations.

Ort, förlag, år, upplaga, sidor
Wiley-Blackwell, 2016. Vol. 46, nr 12, s. 1540-1548
Nyckelord [en]
asthma, clinical immunology, epidemiology
Nationell ämneskategori
Arbetsmedicin och miljömedicin Lungmedicin och allergi Immunologi inom det medicinska området
Identifikatorer
URN: urn:nbn:se:umu:diva-125119DOI: 10.1111/cea.12792ISI: 000389203600005PubMedID: 27513280OAI: oai:DiVA.org:umu-125119DiVA, id: diva2:958129
Tillgänglig från: 2016-09-06 Skapad: 2016-09-06 Senast uppdaterad: 2018-06-07Bibliografiskt granskad

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Sommar, Johan

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Clinical and Experimental Allergy
Arbetsmedicin och miljömedicinLungmedicin och allergiImmunologi inom det medicinska området

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