Increased plasmid copy number is essential for Yersinia T3SS function and virulenceVisa övriga samt affilieringar
2016 (Engelska)Ingår i: Science, ISSN 0036-8075, E-ISSN 1095-9203, Vol. 353, nr 6298, s. 492-495Artikel i tidskrift (Refereegranskat) Published
Abstract [en]
Pathogenic bacteria have evolved numerous virulence mechanisms that are essential for establishing infections. The enterobacterium Yersinia uses a type III secretion system (T3SS) encoded by a 70-kilobase, low-copy, IncFII-class virulence plasmid. We report a novel virulence strategy in Y. pseudotuberculosis in which this pathogen up-regulates the plasmid copy number during infection. We found that an increased dose of plasmid-encoded genes is indispensable for virulence and substantially elevates the expression and function of the T3SS. Remarkably, we observed direct, tight coupling between plasmid replication and T3SS function. This regulatory pathway provides a framework for further exploration of the environmental sensing mechanisms of pathogenic bacteria.
Ort, förlag, år, upplaga, sidor
2016. Vol. 353, nr 6298, s. 492-495
Nationell ämneskategori
Mikrobiologi inom det medicinska området Infektionsmedicin
Identifikatorer
URN: urn:nbn:se:umu:diva-125586DOI: 10.1126/science.aaf7501ISI: 000380583600042PubMedID: 27365311Scopus ID: 2-s2.0-84976871025OAI: oai:DiVA.org:umu-125586DiVA, id: diva2:971790
2016-09-192016-09-132023-03-24Bibliografiskt granskad