Change search
ReferencesLink to record
Permanent link

Direct link
Renal cell carcinoma recurrences and metastases in primary non-metastatic patients: a population-based study
Show others and affiliations
2016 (English)In: World journal of urology, ISSN 0724-4983, E-ISSN 1433-8726, Vol. 34, no 8, 1081-1086 p.Article in journal (Refereed) Published
Abstract [en]

To present the occurrence of metastases and local recurrences in primary non-metastatic patients with renal cell carcinoma (RCC) in a contemporary Swedish population-based cohort. Between 2005 and 2009, a total of 4527 patients were included in the prospective National Swedish Kidney Cancer Register accounting for nearly all RCC patients in Sweden. Among M0 patients, 472 (13 %) had no follow-up data registered within 5-year follow-up time and were excluded from the analysis. In total, 939 (21 %) had distant metastases at presentation with a decrease from 23 to 18 % during the inclusion period. Of 3107 patients with follow-up data and with M0 disease, 623 (20 %) were diagnosed with a tumor recurrence during 5-year follow-up. Mean time to recurrence was 24 months (SD +/- A 20 months). Among these, 570 patients (92 %) were at primary diagnosis treated with radical nephrectomy, 23 patients (3.7 %) with partial nephrectomy and 12 patients (1.9 %) with minimally invasive treatments. The most frequent sites of metastases were lung (54 %), lymph nodes (22 %) and bone (20 %). The treatment of recurrence was in 50 % systemic treatments, while metastasectomy was performed in 17 % of the patients, out of which 68 % were with a curative intention. In this population-based study, 21 % of the patients had metastatic disease at presentation, with a decreasing trend over the study period. During 5-year follow-up, 20 % of the primary non-metastatic patients had recurrent disease. Of the patients with recurrence, half were given systemic oncological treatment and 17 % underwent metastasectomy.

Place, publisher, year, edition, pages
2016. Vol. 34, no 8, 1081-1086 p.
Keyword [en]
Renal cell carcinoma, Metastases, Recurrent disease, Local recurrence, Surgery, Nephrectomy, Partial nephrectomy, Minimal invasive therapy
National Category
Cancer and Oncology
URN: urn:nbn:se:umu:diva-125972DOI: 10.1007/s00345-016-1773-yISI: 000381101100006PubMedID: 26847337OAI: diva2:1037190
Available from: 2016-10-14 Created: 2016-09-23 Last updated: 2016-10-14Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Ljungberg, Börje
By organisation
Urology and Andrology
In the same journal
World journal of urology
Cancer and Oncology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

ReferencesLink to record
Permanent link

Direct link