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Clear cell variant of intraosseous calcifying epithelial odontogenic tumor: a case report and review of the literature.
Department of Odontology, Oral and Maxillofacial Surgery, Umeå University Hospital, Umeå, Sweden.
2016 (English)In: Oral surgery, oral medicine, oral pathology and oral radiology, ISSN 2212-4403, E-ISSN 2212-4411, Vol. 122, no 4, E125-E130 p.Article in journal (Refereed) Published
Abstract [en]

CEOT is a rare benign, but locally aggressive odontogenic tumor, and some authors have claimed that the biologic behavior of the clear cell variant is even more aggressive, with greater propensity to recur. We report a rare case of clear cell calcifying epithelial odontogenic tumor (CEOT) and discuss its possibly aggressive behavior. A 40-year-old woman experienced an asymptomatic expansion of the left posterior mandible. After radiographic examination and biopsy, a block resection was performed. Histologic examination included analysis of Ki-67 reactivity as a marker of tumor growth activity. Ki-67 labeling was pronounced in the non-clear cell population in the tumor periphery but low in the central and clear cell portions. Clinical and radiographic follow-up 6 years after resection has not revealed any signs of recurrence. On the basis of a review of the literature and our own findings, there is no clear data to suggest that clear cell CEOT exhibits more aggressive behavior compared with conventional CEOT.

Place, publisher, year, edition, pages
Elsevier, 2016. Vol. 122, no 4, E125-E130 p.
National Category
URN: urn:nbn:se:umu:diva-127018DOI: 10.1016/j.oooo.2016.01.001ISI: 000389530900005PubMedID: 26953043OAI: diva2:1040001
Available from: 2016-10-26 Created: 2016-10-26 Last updated: 2017-01-09Bibliographically approved

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Sjöström, Mats
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