umu.sePublications
Change search
ReferencesLink to record
Permanent link

Direct link
Epigenome-wide analysis of DNA methylation reveals a rectal cancer-specific epigenomic signature
Show others and affiliations
2016 (English)In: Epigenomics, ISSN 1750-1911, Vol. 8, no 9, 1193-1207 p.Article in journal (Refereed) Published
Abstract [en]

Aim: The aim of the present study is to address a genome-wide search for novel methylation biomarkers in the rectal cancer (RC), as only scarce information on methylation profile is available. Materials & methods: We analyzed methylation status in 25 pairs of RC and adjacent healthy mucosa using the Illumina Human Methylation 450 BeadChip. Results: We found significantly aberrant methylation in 33 genes. After validation of our results by pyrosequencing, we found a good agreement with our findings. The BPIL3 and HBBP1 genes resulted hypomethylated in RC, whereas TIFPI2, ADHFE1, FLI1 and TLX1 were hypermethylated. An external validation by TCGA datasets confirmed the results. Conclusion: Our study, with external validation, has demonstrated the feasibility of using specific methylated DNA signatures for developing biomarkers in RC.

Place, publisher, year, edition, pages
2016. Vol. 8, no 9, 1193-1207 p.
National Category
Medical Bioscience
Identifiers
URN: urn:nbn:se:umu:diva-126504DOI: 10.2217/epi-2016-0044ISI: 000383180400005PubMedID: 27529132OAI: oai:DiVA.org:umu-126504DiVA: diva2:1040432
Available from: 2016-10-27 Created: 2016-10-10 Last updated: 2016-10-27Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Nilsson, Torbjorn K.
By organisation
Department of Medical Biosciences
In the same journal
Epigenomics
Medical Bioscience

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 2 hits
ReferencesLink to record
Permanent link

Direct link