umu.sePublications
Change search
ReferencesLink to record
Permanent link

Direct link
NEK1 variants confer susceptibility to amyotrophic lateral sclerosis
Show others and affiliations
2016 (English)In: Nature Genetics, ISSN 1061-4036, E-ISSN 1546-1718, Vol. 48, no 9, 1037-1042 p.Article in journal, Letter (Refereed) Published
Abstract [en]

To identify genetic factors contributing to amyotrophic lateral sclerosis (ALS), we conducted whole-exome analyses of 1,022 index familial ALS (FALS) cases and 7,315 controls. In a new screening strategy, we performed gene-burden analyses trained with established ALS genes and identified a significant association between loss-of-function (LOF) NEK1 variants and FALS risk. Independently, autozygosity mapping for an isolated community in the Netherlands identified a NEK1 p.Arg261 His variant as a candidate risk factor. Replication analyses of sporadic ALS (SALS) cases and independent control cohorts confirmed significant disease association for both p.Arg261 His (10,589 samples analyzed) and NEK1 LOF variants (3,362 samples analyzed). In total, we observed NEK1 risk variants in nearly 3% of ALS cases. NEK1 has been linked to several cellular functions, including cilia formation, DNA-damage response, microtubule stability, neuronal morphology and axonal polarity. Our results provide new and important insights into ALS etiopathogenesis and genetic etiology.

Place, publisher, year, edition, pages
2016. Vol. 48, no 9, 1037-1042 p.
National Category
Medical Genetics
Identifiers
URN: urn:nbn:se:umu:diva-126319DOI: 10.1038/ng.3626ISI: 000382398800014PubMedID: 27455347OAI: oai:DiVA.org:umu-126319DiVA: diva2:1044174
Available from: 2016-11-02 Created: 2016-10-03 Last updated: 2016-11-02Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Sendtner, MichaelAndersen, Peter M.
By organisation
Department of Pharmacology and Clinical Neuroscience
In the same journal
Nature Genetics
Medical Genetics

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 2 hits
ReferencesLink to record
Permanent link

Direct link