Change search
ReferencesLink to record
Permanent link

Direct link
Structural but not functional neuroplasticity one year after effective cognitive behaviour therapy for social anxiety disorder
Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI). Aging Research Center, Karolinska Institutet, Stockholm, Sweden.
Umeå University, Faculty of Social Sciences, Centre for Demographic and Ageing Research (CEDAR). Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI). Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Denmark.ORCID iD: 0000-0002-4458-6475
Show others and affiliations
2017 (English)In: Behavioural Brain Research, ISSN 0166-4328, E-ISSN 1872-7549, Vol. 318, 45-51 p.Article in journal (Refereed) Published
Abstract [en]

Effective psychiatric treatments ameliorate excessive anxiety and induce neuroplasticity immediately after the intervention, indicating that emotional components in the human brain are rapidly adaptable. Still, the interplay between structural and functional neuroplasticity is poorly understood, and studies of treatment-induced long-term neuroplasticity are rare. Functional and structural magnetic resonance imaging (using 3 T MRI) was performed in 13 subjects with social anxiety disorder on 3 occasions over 1 year. All subjects underwent 9 weeks of Internet-delivered cognitive behaviour therapy in a randomized cross-over design and independent assessors used the Clinically Global Impression-Improvement (CGI-I) scale to determine treatment response. Gray matter (GM) volume, assessed with voxel-based morphometry, and functional blood-oxygen level-dependent (BOLD) responsivity to self-referential criticism were compared between treatment responders and non-responders using 2 × 2 (group × time; pretreatment to follow-up) ANOVA. At 1-year follow-up, 7 (54%) subjects were classified as CGI-I responders. Left amygdala GM volume was more reduced in responders relative to non-responders from pretreatment to 1-year follow-up (Z = 3.67, Family-Wise Error corrected p = 0.02). In contrast to previous short-term effects, altered BOLD activations to self-referential criticism did not separate responder groups at follow-up. The structure and function of the amygdala changes immediately after effective psychological treatment of social anxiety disorder, but only reduced amygdala GM volume, and not functional activity, is associated with a clinical response 1 year after CBT.

Place, publisher, year, edition, pages
2017. Vol. 318, 45-51 p.
Keyword [en]
Amygdala, Neuroplasticity, Long-term, Social anxiety disorder, Cognitive behavior therapy
National Category
URN: urn:nbn:se:umu:diva-127341DOI: 10.1016/j.bbr.2016.11.018OAI: diva2:1045313
Available from: 2016-11-08 Created: 2016-11-08 Last updated: 2017-02-02Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Salami, AlirezaBoraxbekk, Carl-Johan
By organisation
Umeå Centre for Functional Brain Imaging (UFBI)Centre for Demographic and Ageing Research (CEDAR)
In the same journal
Behavioural Brain Research

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 20 hits
ReferencesLink to record
Permanent link

Direct link