Evaluation of a novel chamber setup for human exposures of biomass combustion aerosols
(English)Manuscript (preprint) (Other academic)
Based on a vast number of epidemiological studies there is today a consensus that increased concentrations of ambient particulate matter air pollution cause adverse health effects such as mortality, hospitalizations, cardiovascular events, respiratory symptoms and reduced lung function. The use of controlled laboratory studies with human exposure chambers can give unique opportunities to directly examine specific exposure conditions and cause-effect relationship with relevant concentrations and particle types. In this paper, the design of a novel chamber setup for human exposures of biomass combustion aerosols is described with an evaluation of the systems function under different conditions (e.g. air exchange rates and target PM1 concentrations). Several different research biomass combustion systems are available in combination with extensive and advanced monitoring and characterization of the gaseous and particle emissions used for exposures. Examples, with data from three performed human exposure campaigns, are included and discussed as a basis for the evaluation of the whole setup, with the target to generate stable conditions in the chamber using different kinds of biomass combustion aerosols. Based on the evaluation of function and present exposure experiences it can be concluded that the chamber setup and biomass aerosol generation systems is able to produce a stable aerosol concentration in the chamber of different particle types. Overall, the human exposure setup for biomass combustion aerosols together with the integrated biomass combustion laboratory gives extensive possibilities for designing different whole body human exposure studies for a variety of biomass combustion aerosols as well as other experimental aerosol research.
Respiratory Medicine and Allergy Energy Engineering
IdentifiersURN: urn:nbn:se:umu:diva-127361OAI: oai:DiVA.org:umu-127361DiVA: diva2:1045493