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Transcriptional regulation of the human acetoacetyl-CoA synthetase gene by PPARgamma.
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2010 (English)In: Biochemical Journal, ISSN 0264-6021, E-ISSN 1470-8728, Vol. 427, no 2Article in journal (Refereed) Published
Abstract [en]

In the cytosol of lipogenic tissue, ketone bodies are activated by AACS (acetoacetyl-CoA synthetase) and incorporated into cholesterol and fatty acids. AACS gene expression is particularly abundant in white adipose tissue, as it is induced during adipocyte differentiation. In order to elucidate the mechanism controlling the gene expression of human AACS and to clarify its physiological role, we isolated the human promoter, characterized the elements required to initiate transcription and analysed the expression of the gene in response to PPARgamma (peroxisome-proliferator-activated receptor gamma), an inducer of adipogenesis. We show that the human AACS promoter is a PPARgamma target gene and that this nuclear receptor is recruited to the AACS promoter by direct interaction with Sp1 (stimulating protein-1).

Place, publisher, year, edition, pages
2010. Vol. 427, no 2
National Category
Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:umu:diva-128217DOI: 10.1042/BJ20090851PubMedID: 20102333OAI: oai:DiVA.org:umu-128217DiVA: diva2:1050590
Available from: 2016-11-29 Created: 2016-11-29 Last updated: 2016-11-29

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Aguiló, Francesca
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