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Diet Quality Scores and Prediction of All-Cause, Cardiovascular and Cancer Mortality in a Pan-European Cohort Study
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2016 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 11, no 7, e0159025Article in journal (Refereed) Published
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Abstract [en]

Scores of overall diet quality have received increasing attention in relation to disease aetiology; however, their value in risk prediction has been little examined. The objective was to assess and compare the association and predictive performance of 10 diet quality scores on 10-year risk of all-cause, CVD and cancer mortality in 451,256 healthy participants to the European Prospective Investigation into Cancer and Nutrition, followed-up for a median of 12.8y. All dietary scores studied showed significant inverse associations with all outcomes. The range of HRs (95% CI) in the top vs. lowest quartile of dietary scores in a composite model including non-invasive factors (age, sex, smoking, body mass index, education, physical activity and study centre) was 0.75 (0.72-0.79) to 0.88 (0.84-0.92) for all-cause, 0.76 (0.69-0.83) to 0.84 (0.76-0.92) for CVD and 0.78 (0.73-0.83) to 0.91 (0.85-0.97) for cancer mortality. Models with dietary scores alone showed low discrimination, but composite models also including age, sex and other non-invasive factors showed good discrimination and calibration, which varied little between different diet scores examined. Mean C-statistic of full models was 0.73, 0.80 and 0.71 for all-cause, CVD and cancer mortality. Dietary scores have poor predictive performance for 10-year mortality risk when used in isolation but display good predictive ability in combination with other non-invasive common risk factors.

Place, publisher, year, edition, pages
2016. Vol. 11, no 7, e0159025
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Nutrition and Dietetics Public Health, Global Health, Social Medicine and Epidemiology
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URN: urn:nbn:se:umu:diva-124326DOI: 10.1371/journal.pone.0159025ISI: 000379508300050OAI: oai:DiVA.org:umu-124326DiVA: diva2:1052303
Available from: 2016-12-06 Created: 2016-08-04 Last updated: 2016-12-06Bibliographically approved

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Nilsson, Lena MariaRenström, Frida
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Nutritional Research
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Citation style
  • apa
  • ieee
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  • Other style
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Language
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  • Other locale
More languages
Output format
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