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Association between gastrointestinal symptoms and affectivity in patients with bipolar disorder
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Medicine.
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Psychiatry.
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Psychiatry.
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Psychiatry.
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2016 (English)In: World Journal of Gastroenterology, ISSN 1007-9327, E-ISSN 2219-2840, Vol. 22, no 38, 8540-8548 p.Article in journal (Refereed) Published
Abstract [en]

AIM: To study if anxiety, depression and experience of stress are associated with gastrointestinal (GI) symptoms in patients with bipolar disorder.

METHODS: A total of 136 patients with bipolar disorder (mean age 49.9 years; 61% women) and 136 controls from the general population (mean age 51.0 years; 60% women) were included in the study. GI symptoms were assessed with The Gastrointestinal Symptom Rating Scale-irritable bowel syndrome (GSRS-IBS), level of anxiety and depression with The Hospital Anxiety and Depression Scale (HADS) and stress-proneness with Perceived Stress Questionnaire. Over a ten year period, all visits in primary care were retrospectively recorded in order to identify functional GI disorders.

RESULTS: In subjects with low total HADS-score, there were no significant differences in GI-symptoms between patients and controls (GSRS-IBS 7.0 vs 6.5, P = 0.513). In the patients with bipolar disorder there were significant correlations between all GSRS and HADS subscores for all symptom clusters except for "constipation" and "reflux". Factors associated to GI symptoms in the patient group were female sex (adjusted OR = 2.37, 95%CI: 1.07-5.24) and high HADS-Depression score (adjusted OR = 3.64, 95%CI: 1.07-12.4). These patients had also significantly more visits for IBS than patients with low HADS-Depression scores (29% vs 8%, P = 0.008). However, there was no significant differences in consulting behaviour for functional GI disorders between patients and controls (25% vs 17%, P = 0.108).

CONCLUSION: Female patients and patients with high HADS depression score reported significantly more GI symptoms, whereas patients with low HADS scores did not differ from control subjects.

Place, publisher, year, edition, pages
Baishideng , 2016. Vol. 22, no 38, 8540-8548 p.
Keyword [en]
Anxiety, Bipolar disorder, Brain-Gut axis, Depression, Dyspepsia, Functional gastrointestinal disorder, Gastrointestinal Symptom Rating Scale- irritable bowel syndrome, Irritable bowel syndrome, Hospital Anxiety and Depression Scale, Stress
National Category
Gastroenterology and Hepatology
Identifiers
URN: urn:nbn:se:umu:diva-128593DOI: 10.3748/wjg.v22.i38.8540ISI: 000386596700010PubMedID: 27784966OAI: oai:DiVA.org:umu-128593DiVA: diva2:1052886
Available from: 2016-12-07 Created: 2016-12-07 Last updated: 2017-01-03Bibliographically approved

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CiteExportLink to record
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